ABE572
抗N6-甲基腺苷(m6A)抗体
from rabbit
别名:
m6A
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Clone:
polyclonal
Technique(s):
ChIP: suitable, RIP: suitable, dot blot: suitable
Application:
ChIP, DB, RIP
Citations:
91
biological source
rabbit
antibody form
purified antibody
antibody product type
primary antibodies
clone
polyclonal
species reactivity (predicted by homology)
all
technique(s)
ChIP: suitable, RIP: suitable, dot blot: suitable
shipped in
wet ice
target post-translational modification
unmodified
General description
N6-甲基腺苷（m6A），或腺苷N6位的甲基化，是RNA的一种转录后修饰。 由于分析方法的缺乏，人们对N6-甲基腺苷了解的很少，但新证据表明它是一种非常常见的碱基修饰和重要的生理调节因子。N6-甲基腺苷在整个大脑发育过程中都会显著增加，并会在终止密码子、microRNA结合位点和UTR附近富集，表明了其在基因表达调节中的基础性作用。N6-甲基腺苷在人和小鼠之间也高度保守。
Immunogen
BSA偶联的N6-甲基腺苷。
Application
染色质免疫沉淀分析：A representative lot from an independent laboratory detected N6-methyladenosine in RNA containing N6-methyladenosine (Dominissini, D., et al. (2012).Nature.485(7397):201-206.; Meyer, K. D., et al. (2012).Cell.149(7):1635-1646.).
(RNA) Immunoprecipitation Analysis: A representative lot from an independent laboratory detected N6-methyladenosine in methylated RNA containing N6-methyladenosine (Meyer, K. D., et al. (2012).Cell.149(7):1635-1646.).
Dot Blot Analysis: A representative lot from an independent laboratory detected N6-methyladenosine in a panel of modified oligonucleotides (Meyer, K. D., et al. (2012).Cell.149(7):1635-1646.; Jia, G., et al. (2011).Nat Chem Biol. 7(12):885-887.).
(RNA) Immunoprecipitation Analysis: A representative lot from an independent laboratory detected N6-methyladenosine in methylated RNA containing N6-methyladenosine (Meyer, K. D., et al. (2012).Cell.149(7):1635-1646.).
Dot Blot Analysis: A representative lot from an independent laboratory detected N6-methyladenosine in a panel of modified oligonucleotides (Meyer, K. D., et al. (2012).Cell.149(7):1635-1646.; Jia, G., et al. (2011).Nat Chem Biol. 7(12):885-887.).
研究子类别
染色质生物学
染色质生物学
研究类别
表观遗传学&核功能
表观遗传学&核功能
通过使用已验证用于斑点印迹、染色质IP（ChIP) & RNA结合蛋白IP（RIP）的抗-N6-甲基腺苷（m6A）抗体检测N6-甲基腺苷（m6A）。
Physical form
在含有0.05%叠氮化钠PBS的缓冲液中的纯化兔多抗。
形式：纯化
纯化的蛋白 A
Preparation Note
自发运之日起，在 2-8°C 条件下可稳定保存1年
Analysis Note
已通过斑点印迹在含有N6-甲基腺苷的低聚物中进行评估。
斑点印迹分析： 1 µg/mL的该抗体可在含有N6-甲基腺苷的低聚物中检测到N6-甲基腺苷。
斑点印迹分析： 1 µg/mL的该抗体可在含有N6-甲基腺苷的低聚物中检测到N6-甲基腺苷。
Other Notes
浓度：请参考批次特异性浓缩物的分析证书。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Hua Su et al.
BMC genomics, 21(1), 39-39 (2020-01-15)
Hypoxia mediated pulmonary hypertension (HPH) is a lethal disease and lacks effective therapy. CircRNAs play significant roles in physiological process. Recently, circRNAs are found to be m6A-modified. The abundance of circRNAs was influenced by m6A. Furthermore, the significance of m6A
Xiaoling Liu et al.
Analytical chemistry, 90(9), 5546-5551 (2018-04-14)
N6-methyladenine (6mA) is a rediscovered DNA modification in eukaryotic genomes. To explore the distribution and functions of 6mA, it is of paramount option to use immunoprecipitation to select 6mA-containing DNA fragments for genome-wide sequencing. Presumably, most of the 6mA-free fragments
Andrea Orioli et al.
Genome research, 26(5), 624-635 (2016-03-05)
RNA polymerase III (Pol III) is tightly controlled in response to environmental cues, yet a genomic-scale picture of Pol III regulation and the role played by its repressor MAF1 is lacking. Here, we describe genome-wide studies in human fibroblasts that
Xiao-Cui Li et al.
Theranostics, 9(13), 3853-3865 (2019-07-10)
N6-Methyladenosine (m6A) is the most prevalent internal modification in mammalian mRNAs. Although m6A is important in many biological processes, its roles in the placenta are unclear. Methods: Levels of global mRNA m6A methylation and ALKBH5 expression in recurrent miscarriage (RM)
Taylor M Nye et al.
PLoS pathogens, 15(6), e1007841-e1007841 (2019-06-18)
DNA methylation is pervasive across all domains of life. In bacteria, the presence of N6-methyladenosine (m6A) has been detected among diverse species, yet the contribution of m6A to the regulation of gene expression is unclear in many organisms. Here we
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