ABE596
Anti-ZEB1 Antibody
from rabbit, purified by affinity chromatography
别名:
Zinc finger E-box-binding homeobox 1, NIL-2-A zinc finger protein, Negative regulator of IL2, Transcription factor 8, TCF-8
产品名称
Anti-ZEB1 Antibody, from rabbit, purified by affinity chromatography
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
human
technique(s)
immunocytochemistry: suitable
immunofluorescence: suitable
western blot: suitable
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... ZEB1(6935)
Analysis Note
Control
HeLa cell lysate
HeLa cell lysate
Evaluated by Western Blotting in HeLa cell lysate.
Western Blotting Analysis: 1 µg/mL of this antibody detected ZEB1 in 15 µg of HeLa cell lysate.
Western Blotting Analysis: 1 µg/mL of this antibody detected ZEB1 in 15 µg of HeLa cell lysate.
Application
Detect ZEB1 using this rabbit polyclonal antibody, Anti-ZEB1 Antibody validated for use in western blotting, ICC & Immunofluorescence.
Immunocytochemistry Analysis: 20 µg/mL from a representative lot detected ZEB1 in HeLa cells.
Immunofluorescence Analysis: 20 μg/mL from a representative lot detected ZEB1 in HeLa cells.
Immunofluorescence Analysis: 20 μg/mL from a representative lot detected ZEB1 in HeLa cells.
Research Category
Epigenetics & Nuclear Function
Epigenetics & Nuclear Function
Research Sub Category
Transcription Factors
Transcription Factors
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Zinc finger E-box-binding homeobox 1 (ZEB1), also known as Transcription factor 8 (TCF8), Negative regulator of IL2, and NIL-2-A zinc finger protein acts as a transcriptional repressor that inhibits interleukin-2 (IL-2) gene expression. ZEB1 has also been implicated in regulating the expression of ATP1A1, E-cadherin, BCL6, and RCOR1 genes. ZEB1 regulates neurogenesis and neuronal differentiation, but is also implicated in tumor formation. ZEB1 is expressed in heart and skeletal muscle. Mutations in ZEB1 have been associated with corneal dystrophy.
~130 kDa observed. Uncharacterized bands may appear in some lysate(s). Uniprot describes two isoforms at ~124 kDa
Immunogen
KLH-conjugated linear peptide corresponding to human ZEB1 .
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Physical form
Antigen Affinity Purified
Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
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存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Hong Chang et al.
Scientific reports, 6, 22312-22312 (2016-03-01)
MicroRNAs are small and non-coding RNA molecules with the master role in regulation of gene expression at post-transcriptional/translational levels. Many methods have been developed for microRNA loss-of-function study, such as antisense inhibitors and sponges; however, the robustness, specificity, and stability
Xin Yao et al.
Oncotarget, 8(42), 72235-72249 (2017-10-27)
The Transducin-like enhancer of split 1 (TLE1) corepressor protein is overexpressed in human lung tumors and is a putative lung-specific oncogene. However, the molecular mechanism underlying its oncogenic function remains to be delineated. Here, we report an important role of
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