ABN209
Anti-TTC8 Antibody
from rabbit, purified by affinity chromatography
别名:
Tetratricopeptide repeat protein 8, TPR repeat protein 8, Bardet-Biedl syndrome 8 protein, TTC8
产品名称
Anti-TTC8 Antibody, from rabbit, purified by affinity chromatography
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
horse, mouse, human
species reactivity (predicted by homology)
primate (based on 100% sequence homology), porcine (based on 100% sequence homology), equine (based on 100% sequence homology)
technique(s)
immunohistochemistry: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... TTC8(123016)
Analysis Note
Control
ARPE19 tissue lysate
ARPE19 tissue lysate
Evaluated by Western Blot in ARPE19 tissue lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected TTC8 in 10 µg of ARPE19 tissue lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected TTC8 in 10 µg of ARPE19 tissue lysate.
Application
Anti-TTC8 detects levels of TTC8 proteins & has been published & validated for use in WB & IHC.
Immunohistochemistry Analysis: A 1:2,000 dilution from a representative lot detected TTC8 in human prostate cancer and mouse eye tissues.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Cytoskeleton
Cytoskeleton
Biochem/physiol Actions
Other homologies: Rat (53% sequence homology).
This antibody recognizes the TPR1 domain of TTC8.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Also known as tetratricopeptide repeat protein 8, TTC8 is a BBSome complex that is required for ciliogenesis. It is known to associate with the Rab8 GDP/GTP exchange factor, which is localized in the basal body. Rab8(GTP) is produced and enters the primary cilium, where it promotes ciliary membrane biogenesis. Mutations in TTC8 have been identified in Bardet-Biedl syndrome (BBS), a genetic disorder which is characterized with obesity, retinal degeneration, and nephropathy.
~61 kDa observed. Uncharacterized bands at ~270 kDa, ~160 kDa, and ~38 kDa may be observed in some cell lysates.
Immunogen
Epitope: TPR1 domain
KLH-conjugated linear peptide corresponding to the TPR1 domain of human TTC8.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Physical form
Affinity purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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