Anti-LRFN4 Antibody

LRFN4 is one of a family of five transmembrane glycoproteins that are highly expressed in neuronal tissues. LRFN proteins share leucine-rich repeat (LRR)-immunoglobulin-like (Ig)-fibronectin type III (Fn)-transmembrane domain structure with other members of the LRR-Ig-Fn protein superfamily such as the Slitrk family of proteins. Expression of LRFN1, -3, and -4 mRNA was detected in embryonic neuronal cells, while LRFN2 and LRFN5 expression was primarily restricted to more mature cells. LRFN1, -2, and -4 bound to PDZ domains of postsynaptic PSD95, re-distributing PSD95 to the cell periphery. It has been suggested that the LRFN proteins play a role in the developing and/or mature vertebrate nervous system.

~80 kDa observed. Uncharacterized bands may appear between ~40 and ~160 kDa in some lysates. The calculated molecular weight of this protein is 66 kDa, but can be observed at ~80 kDa due to high glycosylation.

KLH-conjugated linear peptide corresponding to human LRFN4.

Detect the LRFN4 protein using this Anti-LRFN4 validated for use in WB & IHC.

Immunohistochemistry Analysis: 2.5 µg/mL from a representative lot detected LRFN4 in mouse brain tissue.

Research Category
Neuroscience

Research Sub Category
Developmental Neuroscience

This antibody is predicted to not cross-react with other members of the LRFN family.

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS with 0.02% sodium azide.

Stable for 1 year at 2-8°C from date of receipt.

Control
Mouse brain tissue lysate

Evaluated by Western Blot in mouse brain tissue lysate.

Western Blot Analysis: 1 µg/mL of this antibody detected LRFN4 in 10 µg/mL of mouse brain tissue lysate.

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.