Anti-SNORC

Protein SNORC (UniProt: Q9CXL7; also known as Secondary ossification center-associated regulator of chondrocyte maturation protein) is encoded by the Snorc gene (Gene ID: 73234) in murine species. SNORC is a highly conserved, single-pass membrane protein that is synthesized with a signal peptide (aa 1-24), which is subsequently cleaved off to generate the mature form that contains an extracellular domain (aa 25-92), a transmembrane domain (aa 93-113), and a short cytoplasmic domain (aa 114-121). It contains a highly conserved glycosaminoglycan (GAG) attached to serine 44. Its expression is observed only in cartilage and plays a role in the regulation of chondrocyte maturation and postnatal endochondral ossification. It is reported that SNORC is not essential during early differentiation and its function pertains more to mature chondrocytes. (Ref.: Jaiswal, PK., et al. (2020). Sci. Rep. 10; Article 7790).

His-tagged recombinant fragment corresponding to 67 amino acids from the extracellular domain of murine SNORC protein.

Quality Control TestingEvaluated by Western Blotting in lysate from HEK293 cells expressing the untagged Mouse SNORC.Western Blotting Analysis: A 1:1,000 dilution of this antibody detected SNORC in lysate from HEK293 cells expressing the untagged Mouse SNORC.Tested ApplicationWestern Blotting Analysis: A 1:10,000 dilution from a representative lot detected SNORC in 3xFlag mouse-SNORC (Courtesy of Dr. Pierre Moffatt; Shriners Hospitals for Children and McGill University, Montreal, Canada).Immunocytochemistry Analysis: A representative lot detected SNORC in Immunocytochemistry applications (Jaiswal, P.K., et. al. (2020). Sci Rep. 10(1):7790).Immunohistochemistry (Paraffin) Analysis: A 1:3,000 dilution from a representative lot detected SNORC in Mouse Decalcified Femur (Global KO) (Courtesy of Dr. Pierre Moffatt; Shriners Hospitals for Children and McGill University, Montreal, Canada).Immunohistochemistry Applications: A representative lot detected SNORC in Immunohistochemistry applications (Jaiswal, P.K., et. al. (2020). Sci Rep. 10(1):7790).Western Blotting Analysis: A representative lot detected SNORC in Western Blotting applications (Jaiswal, P.K., et. al. (2020). Sci Rep. 10(1):7790).Note: Actual optimal working dilutions must be determined by end user as specimens, and experimental conditions may vary with the end user

Anti-SNORC, Cat. No. ABS2249, is a rabbit polyclonal antibody that detects SNORC and is tested for use in Western Blotting, Immunocytochemistry, Immunohistochemistry (Paraffin), and Western Blotting.

This rabbit polyclonal antibody detects secondary ossification center-associated regulator of chondrocyte maturation protein (SNORC). It targets an epitope within 67 amino acids from the extracellular domain.

Purified rabbit polyclonal antibody in PBS with 0.05% sodium azide.

Stable for 1 year at +2°C to +8°C from date of receipt.

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.