ABS446
Anti-GPVI Antibody
from rabbit, purified by affinity chromatography
别名:
GPVI Antibody, Glycoprotein VI, GPIV, Platelet glycoprotein VI precursor, GP6, Glycoprotein 6
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
纯化方式
affinity chromatography
种属反应性
mouse, human
技术
immunofluorescence: suitable
immunohistochemistry: suitable
western blot: suitable
UniProt登记号
运输
wet ice
靶向翻译后修饰
unmodified
基因信息
human ... GP6(51206)
一般描述
Glycoprotein 6 (GP6), or glycoprotein VI (GPVI), is a member of the immunoglobulin gene superfamily, closely related to Fc receptor gamma chain (FcRgamma) and natural killer receptors. GP6 is a collagen receptor involved in collagen-induced platelet adhesion and activation, and may contribute to arterial and venous thrombus formation. GP6 is a membrane glycoprotein that plays a crucial role in platelet procoagulant activity and subsequent thrombin and fibrin formation. GP6 is expressed in megakaryocytes and platelets. The signaling pathway of GP6 involves the FcRgamma, the Src kinases (likely Fyn/Lyn), the adapter protein LAT and leads to the activation of phospholipase C gamma2. It has been shown that bleeding disorders such as Bleeding Disorder Platelet-Type 11 (BDPLT11), a mild to moderate bleeding disorder caused by defective platelet activation and aggregation in response to collagen, is caused by defects in GP6.
~115 kDa observed. Uniprot describes 3 isoforms at ~35 kDa, ~37 kDa, and ~67 kDa
免疫原
KLH-conjugated linear peptide corresponding to the C-terminus of human GPVI.
应用
Anti-GPVI Antibody is a highly specific rabbit polyclonal antibody, that targets Glycoprotein 6 & has been tested in western blotting, IHC & Immunofluorescence.
Immunohistochemistry Analysis: 10 µg/mL from a representative lot detected GPVI in human heart tissue.
Immunofluorescence Analysis: 20 μg/mL from a representative lot detected GPVI in human heart cells.
Immunofluorescence Analysis: 20 μg/mL from a representative lot detected GPVI in human heart cells.
生化/生理作用
This antibody recognizes the C-terminus of GPVI.
分析说明
Evaluated by Western Blotting/Peptide Inhibition Assay in A20 cell lysate.
Western Blotting/Peptide Inhibition Assay Analysis: 1 µg/mL of this antibody detected GPVI in 15 µg of A20 cell lysate.
Western Blotting/Peptide Inhibition Assay Analysis: 1 µg/mL of this antibody detected GPVI in 15 µg of A20 cell lysate.
其他说明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Replaces: MABT473
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储存分类代码
10 - Combustible liquids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Biswajit Saha et al.
Science advances, 7(30) (2021-07-23)
Platelets extravasate from the circulation into tumor microenvironment, enable metastasis, and confer resistance to chemotherapy in several cancers. Therefore, arresting tumor-platelet cross-talk with effective and atoxic antiplatelet agents in combination with anticancer drugs may serve as an effective cancer treatment
Benjamin E J Spurgeon et al.
Current protocols, 1(5), e112-e112 (2021-05-06)
Platelets are small blood cells that contribute to hemostasis, immunity, and inflammation. Characterization of platelet surface markers allows for differentiation of activated platelets from resting platelets, diagnosis of platelet disorders, and investigation of platelet biology and pathology. In this article
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