biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
mouse, rat
technique(s)
immunocytochemistry: suitable, western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
mouse ... Ltbp1(268977)
General description
潜在转化生长因子β结合蛋白1(LTBP-1)也称为转化生长因子β-1结合蛋白1(TGF-β1-BP1)。来自血小板的TGFB1的大型潜在复合物由与TGFB1前体N末端前肽和LTBP1的二聚体的二硫键复合物非共价结合的TGFB1分子组成。LTBP1不会直接与活性TGFB1结合,而只会与形式结合。LTBP1似乎参与了TGFB1向其储存或激活位点的分泌,并且对于控制TGFB1的作用至关重要。LTBP1还可能在细胞外基质构建和钙结合介导的围绕TGFB1激活的信号通路的信号传导中起作用。此外,由于其在TGFB1代谢中的关键作用,LTBP1在许多发育过程(包括胚胎植入和生长)中都起着重要作用。LTBP1还是至少两个不同的乳腺癌转移特征的参与者,并且具有长亚型和短亚型,可在包括乳腺发育在内的许多组织发育过程中建立和维持TGFbeta生物利用度的空间限制。
观测值〜190 kDa。某些裂解液可能会出现未表征的条带。
Immunogen
对应于大鼠LTBP1铰链区的线性肽。
Application
免疫细胞化学分析:一个代表性批次在大鼠FRC和MG63细胞中检测到LTBP1铰链区(Dallas,S.,et al.(2000).Journal of Bone and Mineral.15(1):68-81)。
该抗LTBP1抗体经过验证可用在WB,IC中检测 LTBP1。
Analysis Note
通过蛋白质印迹在 NIH/3T3 细胞裂解液中进行了评估。
蛋白质印迹分析:0.5 µg/mL该抗体在10 µg NIH/3T3细胞裂解液中检测到LTBP1铰链区。
蛋白质印迹分析:0.5 µg/mL该抗体在10 µg NIH/3T3细胞裂解液中检测到LTBP1铰链区。
Other Notes
浓度:请参考特定批次的数据表。
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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