biological source
chicken
form
liquid
manufacturer/tradename
Chemicon®
concentration
100 μg/mL
technique(s)
ELISA: suitable
cell culture | mammalian: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
Gene Information
chicken ... NCAN(395493)
Analysis Note
来自鸡脑的硫酸软骨素蛋白聚糖的混合物(Chemicon CC117)通过此类分子的独特密度和大小进行纯化。 使用固定的单克隆抗体从该混合物中纯化神经蛋白聚糖。 所得神经蛋白聚糖是纯的,并附有硫酸软骨素。 用软骨素酶去除硫酸软骨素,导致核心蛋白主要是全长250 kD形式和一些较小的神经蛋白聚糖片段。
Application
在以下条件下抑制细胞间粘附、细胞-ECM粘附或细胞迁移:
0.1-30 微克/ mL。
ELISA试验:0.05-5微克/mL
最佳工作浓度必须由最终用户确定。
0.1-30 微克/ mL。
ELISA试验:0.05-5微克/mL
最佳工作浓度必须由最终用户确定。
研究子类别
神经退行性疾病
神经退行性疾病
研究类别
神经科学
神经科学
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
产品来源:鸡脑。
神经蛋白聚糖,鸡。
Physical form
PBS中纯化的神经蛋白聚糖。不含防腐剂。
Preparation Note
以未稀释的等分试样保存于-20°C下12个月。应避免反复冻/融循环。
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
H Ernst et al.
Journal of cell science, 108 ( Pt 12), 3807-3816 (1995-12-01)
Chondroitin sulfate proteoglycans inhibit the adhesion of cells to extracellular matrix proteins that otherwise permit adhesion. Although proteoglycans are widely assumed to act by masking the other protein in a mixed substrate, recent studies suggest that proteoglycans inhibit adhesion through
E U Sumer et al.
Osteoarthritis and cartilage, 15(2), 212-221 (2006-09-26)
Aggrecan is the major proteoglycan in articular cartilage and is known to be degraded by various proteases, including matrix metalloproteinases (MMPs). The present study was undertaken to develop immunoassays detecting aggrecan and its fragments generated by MMP and non-MMP-mediated proteolysis.
The interaction of the retina cell surface N-acetylgalactosaminylphosphotransferase with an endogenous proteoglycan ligand results in inhibition of cadherin-mediated adhesion.
Balsamo, J, et al.
The Journal of cell biology, 129, 1391-1401 (1995)
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