Apolipoprotein E, human

Apolipoprotein E (Apo E) is a multifunctional protein and exists in 3 isoforms namely apoE2, apoE3, and apoE4. It is the constituent of plasma lipoproteins. Apo E is produced by various tissues and is majorly found in interstitial fluid and lymph. It is released in a lipid-poor form.

Apolipoprotein E, human has been used as a standard for the quantification of ApoE protein in the sucrose density gradient (SDG) fractions and the unfractionated brain homogenates using an in-house developed sandwich enzyme-linked immunosorbent assay (ELISA). It has also been used in western blotting to assess its exogenous effects on low-density lipoprotein (LDL)-heparin interactions.

Apolipoprotein E (Apo E) serves as a ligand for low-density receptors and participates in the transport and redistribution of cholesterol and other lipids. It is thought to be involved in tissue repair as increased amounts of the protein are found at sites or peripheral nerve injury and regeneration. A mutant form is associated with type III hyperlipoproteinemia. Apo E plays a crucial role in neurobiology and neurodegenerative diseases.

Liquid in 10 mM NH4HCO3, pH 8.0.

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