产品名称
Anti-GBA Mouse mAb (2E2), liquid, clone 2E2, Calbiochem®
biological source
mouse
antibody form
purified antibody
antibody product type
primary antibodies
clone
2E2, monoclonal
form
liquid
does not contain
preservative
species reactivity
human
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
avoid repeated freeze/thaw cycles
dilution
(ELISA
Immunoblotting (1-5 µg/mL)
Immunocytochemistry (10 µg/mL)
Paraffin Sections (3 µg/mL))
isotype
IgG2a
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... GBA(2629)
Analysis Note
Negative Control
293T
293T
Positive Control
MCF-7 cells, HeLa cells, Human breast cancer tissue
MCF-7 cells, HeLa cells, Human breast cancer tissue
Application
ELISA Immunoblotting (1-5 µg/mL)Immunocytochemistry (10 µg/mL)Paraffin Sections (3 µg/mL)
Disclaimer
Toxicity: Regulatory Review (Z)
General description
Anti-GBA, mouse monoclonal, clone 2E2, recognizes the ~60 kDa GBA in MCF-7 and HeLa cells and human breast cancer tissue. It is validated for use in ELISA, WB, ICC, and IHC on paraffin sections.
Purified mouse monoclonal antibody. Recognizes the ~60 kDa GBA protein.
Recognizes the ~60 kDa GBA protein in MCF-7 and HeLa cells and human breast cancer tissue.
Immunogen
A recombinant polypeptide corresponding to amino acids of 146-236 human GBA, expressed as a GST fusion protein
Other Notes
Campeau, P.M., et al. 2009. Blood114, 3181.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
12 - Non Combustible Liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
Laura J Smith et al.
Human molecular genetics, 32(5), 773-789 (2022-09-22)
Sequence variants or mutations in the GBA gene are numerically the most important risk factor for Parkinson disease (PD). The GBA gene encodes for the lysosomal hydrolase enzyme, glucocerebrosidase (GCase). GBA mutations often reduce GCase activity and lead to the
Ruggero Ferrazza et al.
Biochemical and biophysical research communications, 478(3), 1141-1146 (2016-08-20)
Mutations in LRRK2 gene cause inherited Parkinson's disease (PD) and variations around LRRK2 act as risk factor for disease. Similar to sporadic disease, LRRK2-linked cases show late onset and, typically, the presence of proteinaceous inclusions named Lewy bodies (LBs) in
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