CC050
人胶原蛋白 Ⅰ 型
from human placenta, liquid, 1 mg/mL, suitable for cell culture, used for gel formation
别名:
人类胶原蛋白
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关于此项目
UNSPSC Code:
12352202
eCl@ss:
32160405
NACRES:
NA.75
Biological source:
human
Form:
liquid, solution
Technique(s):
cell culture | mammalian: suitable
Concentration:
1 mg/mL
Assay:
>90% (collagen type I, SDS-PAGE)
产品名称
人胶原蛋白 Ⅰ 型, 1 mg/mL, solution, BioReagent, suitable for cell culture
biological source
human
Quality Segment
assay
>90% (collagen type I, SDS-PAGE)
form
liquid, solution
manufacturer/tradename
Chemicon®
concentration
1 mg/mL
technique(s)
cell culture | mammalian: suitable
impurities
<1% collagen type II,IV-VI & non-collagen proteins., <10% collagen type III
input
sample type pancreatic stem cell(s)
sample type mesenchymal stem cell(s)
sample type epithelial cells
sample type induced pluripotent stem cell(s)
sample type neural stem cell(s)
sample type: human embryonic stem cell(s)
sample type hematopoietic stem cell(s)
solubility
water: soluble at 20 °C
NCBI accession no.
UniProt accession no.
binding specificity
Peptide Source: Elastin
, Peptide Source: Fibronectin
shipped in
dry ice
storage temp.
−20°C
Gene Information
human ... COL1A1(1277)
General description
使用人胎盘胃蛋白酶提取物，通过连续盐沉淀、乙醇沉淀和的 DEAE 色谱法纯化的人 I 型胶原蛋白。胶原蛋白是结缔组织的主要结构蛋白，存在于皮肤、肌腱、软骨、韧带、骨骼、眼球的白色部分（巩膜），以及细胞与组织之间的空间（称为细胞外基质）。它赋予结缔组织的结构和强度。I 型胶原蛋白α1 （COL1A1）基因位于人染色体17q21.33。I 型胶原蛋白在细胞中以前胶原蛋白的形成生成。该蛋白质由两条前体 α1（I）蛋白链与一条前体 α2（I）胶原蛋白前体链结合而成，形成三链绳状结构。在细胞中时，酶通过添加三链形成稳定分子并在链之间建立连接（交联）所必需的化学基团来修饰蛋白质中的某些氨基酸（赖氨酸和脯氨酸）。其他酶会在蛋白质中添加糖。现已完成，三链 I 型胶原蛋白前体分子离开细胞，并通过酶将两端的小片段剪断。原胶蛋白前体分子在细胞外部排列成细长的原纤维。原纤维并排在一起形成胶原纤维。原纤维中分子之间的交联使得蛋白质结构非常稳定，这有助于胶原蛋白的组织增强功能。
Application
Biochem/physiol Actions
I型胶原蛋白α1（COL1A1）基因的突变与I–IV型成骨不全症、VIIA 型 Ehlers-Danlos 综合征、经典型 Ehlers-Danlos 综合征、Caffey 病和特发性骨质疏松症有关。
Physical form
纯化的蛋白质。 含有 0.5 M 醋酸，pH 2.5 的液体。应用时可以在 PBS 中稀释。
Analysis Note
通过 SDS-PAGE 控制纯度，并与抗胶原类型特异性抗体反应
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
This product is regulated in France when intended for scientific purposes, including import, export, and conservation activities (Articles L.1211-1, paragraph 2, and L.1243-4 of the French Public Health Code). The purchaser (i.e. end user) is required to obtain an import authorization from the France Ministry responsible for Research (as referenced in Article L.1245-5-1 II of the French Public Health Code) or a conservation authorization from the same ministry (as referenced in Article L.1243-4 of the French Public Health Code). By placing an order for this product, you confirm that you have obtained the appropriate import or conservation authorization for the product. For more information regarding the use of human biological samples for research purposes in France, please contact the relevant French authorities.
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存储类别
12 - Non Combustible Liquids
WGK
WGK 1
闪点 (F)
Not applicable
闪点 (°C)
Not applicable