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Merck
CN

CC065

Human Tenascin

from human glioma cell line (U251), liquid, 0.1 mg/mL, suitable for cell culture

别名:

TN-C, Tenascin, Hexabrachion, Cytotactin, Neuronectin

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关于此项目

UNSPSC Code:
12352202
eCl@ss:
32160405
NACRES:
NA.75

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产品名称

人Tenascin-C纯化蛋白,

biological source

human

assay

>97% (SDS-PAGE)

form

liquid

mol wt

280—300 kDa

manufacturer/tradename

Chemicon®

concentration

0.1 mg/mL

technique(s)

cell culture | mammalian: suitable

input

sample type induced pluripotent stem cell(s)
sample type mesenchymal stem cell(s)
sample type neural stem cell(s)
sample type pancreatic stem cell(s)
sample type: human embryonic stem cell(s)
sample type epithelial cells
sample type hematopoietic stem cell(s)

solubility

water: soluble

NCBI accession no.

NM_002160.2

UniProt accession no.

P24821

binding specificity

Peptide Source: Fibrinogen

shipped in

dry ice

storage temp.

−70°C

Quality Level

100

Gene Information

human ... TNC(3371)

相关类别

Application

细胞粘连分析。

最佳工作稀释度必须由最终用户进行确定。

Disclaimer

除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

General description

产品来源：人胶质瘤细胞系（U251）。
纯化的人腱生蛋白-C蛋白。已知肌腱蛋白可：1）在中枢神经紧张的系统和间充质来源器官的发育中起积极作用；2）存在于成人肿瘤的脉管系统中；和3）在细胞粘连中起作用。经SDS-PAGE分析，蛋白迁移在280-300kD左右。

Other Notes

替代：CC066

Physical form

纯化的蛋白以不含防腐剂的PBS液体形式提供。

Preparation Note

自收到之日起，在-70ºC可最多保存12个月。 应避免反复冻/融循环。

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

存储类别

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

分析证书(COA)

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Susobhan Sarkar et al.
Cancer research, 77(12), 3231-3243 (2017-04-19)
Oncogenic signaling by NOTCH is elevated in brain tumor-initiating cells (BTIC) in malignant glioma, but the mechanism of its activation is unknown. Here we provide evidence that tenascin-C (TNC), an extracellular matrix protein prominent in malignant glioma, increases NOTCH activity
Longui Ning et al.
BioMed research international, 2019, 1475705-1475705 (2019-12-31)
Tenascin-C (TNC) is an extracellular matrix glycoprotein expressed in response to inflammation and tissue damage. The role of TNC in patients with inflammatory bowel disease (IBD) is not well understood. In this study, we analyzed the expression of TNC in
Azhar Maqbool et al.
World journal of cardiology, 8(5), 340-350 (2016-05-28)
To investigate the effect of Tenascin C (TNC) on the expression of pro-inflammatory cytokines and matrix metalloproteinases in human cardiac myofibroblasts (CMF). CMF were isolated and cultured from patients undergoing coronary artery bypass grafting. Cultured cells were treated with either
So-Young Yeo et al.
Nature communications, 9(1), 3016-3016 (2018-08-03)
Although fibroblasts are dormant in normal tissue, they exhibit explosive activation during wound healing and perpetual activation in pathologic fibrosis and cancer stroma. The key regulatory network controlling these fibroblast dynamics is still unknown. Here, we report that Twist1, a
Janeen H Trembley et al.
Cancer letters, 315(1), 48-58 (2011-11-05)
CK2, a pleiotropic Ser/Thr kinase, is an important target for cancer therapy. We tested our novel tenfibgen-based nanocapsule for delivery of the inhibitor 2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole (DMAT) and an siRNA directed against both CK2α and α' catalytic subunits to prostate cancer cells.
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实验方案

ECM Coating Protocols for Millicell®

This page covers the ECM coating protocols developed for four types of ECMs on Millicell®-CM inserts, Collagen Type 1, Fibronectin, Laminin, and Matrigel.

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