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CC077

人胶原V型

Name: 人胶原V型
Brand: MM

from human placenta, liquid, 1 mg/mL, suitable for cell culture, used for gel formation

别名:

V型胶原蛋白

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关于此项目

UNSPSC Code:

12352202

eCl@ss:

32160405

NACRES:

NA.75

Biological source:

human

Form:

solution

Technique(s):

cell culture | mammalian: suitable

Concentration:

1 mg/mL

Assay:

95% (SDS-PAGE)

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属性

产品名称

人胶原V型, 1 mg/mL, solution, BioReagent, suitable for cell culture

biological source

human

Quality Segment

200

assay

95% (SDS-PAGE)

form

solution

manufacturer/tradename

Chemicon^®

concentration

1 mg/mL

technique(s)

cell culture | mammalian: suitable

impurities

<0.5% non-collagen proteins, <1% collagen type III, <2% collagen type I, <2% collagen type IV

input

sample type mesenchymal stem cell(s)
sample type induced pluripotent stem cell(s)
sample type pancreatic stem cell(s)
sample type epithelial cells
sample type neural stem cell(s)
sample type hematopoietic stem cell(s)
sample type: human embryonic stem cell(s)

NCBI accession no.

NM_000093.3

UniProt accession no.

P20908

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... COL5A1(1289), COL5A2(1290)

说明

General description

V型胶原是纤维型胶原蛋白，存在于肺、骨、胎膜中，与I型胶原共分布。位于细胞外基质，含量偏低。

Application

人类V型胶原蛋白已用于荧光偏振(FP)分析和表面等离子共振(SPR)技术研究高内皮细胞微静脉蛋白(high endothelial venule protein, hevin)和人V型胶原的相互作用。还用于孵育96孔板，用于测定基质和成纤维细胞裂解物中的蛋白水平。

Biochem/physiol Actions

V型胶原可调节角膜和皮肤真皮中的胶原纤维形成。与基质胶原和结构蛋白相互作用，共同维持组织的结构完整性。V型胶原水平偏低会导致角膜透明度的丧失和Ehlers-Danlos综合征（皮肤弹性过度综合征）。

Physical form

液体，在0.1 M醋酸（pH 3.0）中。没有添加防腐剂。

Preparation Note

将未稀释的分装样品保存于-20°C，最长12个月。请勿解冻和重新冷冻。

通过人胎膜胃蛋白酶提取物的连续盐沉淀和DEAE-纤维素色谱纯化。

Other Notes

分子组成：α1(V)]2 α2(V),天然三螺旋。通过SDS-PAGE，ORD测量以及与抗胶原类型特异性单克隆抗体的反应来监测天然螺旋结构的纯度和保留。产品来源：人胎盘，HBsAg和HIV抗体阴性

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

This product is regulated in France when intended for scientific purposes, including import, export, and conservation activities (Articles L.1211-1, paragraph 2, and L.1243-4 of the French Public Health Code). The purchaser (i.e. end user) is required to obtain an import authorization from the France Ministry responsible for Research (as referenced in Article L.1245-5-1 II of the French Public Health Code) or a conservation authorization from the same ministry (as referenced in Article L.1243-4 of the French Public Health Code). By placing an order for this product, you confirm that you have obtained the appropriate import or conservation authorization for the product. For more information regarding the use of human biological samples for research purposes in France, please contact the relevant French authorities.

存储类别

12 - Non Combustible Liquids

WGK

WGK 1

闪点 (F)

Not applicable

闪点 (°C)