CC102A
人整合素αVβ3，辛基-β-D-吡喃葡萄糖苷处方
别名:
Vitronectin Receptor, CD51/CD61
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UNSPSC Code:
12352202
NACRES:
NA.41
eCl@ss:
32160405
Form:
liquid
Assay:
>95% (silver stain, SDS-PAGE)
Biological source:
human
biological source
human
assay
>95% (silver stain, SDS-PAGE)
form
liquid
manufacturer/tradename
Chemicon®
concentration
0.25 mg/mL
NCBI accession no.
UniProt accession no.
Quality Level
Gene Information
human ... ITGAV(3685)
Analysis Note
比活度：通过vWf（von Willibrand因子）结合测定法确认。预期该αvβ3整联蛋白制剂也将以RGD依赖性方式与其他αvβ3结合蛋白相互作用。
Application
电泳和免疫印迹控制。也可用于与金属蛋白酶MMP-2的体外结合实验。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
使用固定的针对αvβ3整联蛋白的单克隆抗体，通过亲和层析从人胎盘中纯化整联蛋白αvβ3。如前所述[Belkin，1990]，制备用于层析柱的组织洗涤剂提取物。 对产品进行检测，发现HIV和肝炎B呈阴性。
Physical form
纯化蛋白溶于含有100 mM辛基-β-D-吡喃葡萄糖苷和叠氮化钠的Tris缓冲盐水。 这种形式的alphaVbeta3适用于功能评估。
Preparation Note
收到货后，在-70°C下以未稀释等分形式可保存长达12个月。应避免反复冻融循环。
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Integrin alphaVbeta3 Binds to the RGD motif of glycoprotein B of Kaposi's sarcoma-associated herpesvirus and functions as an RGD-dependent entry receptor.
H Jacques Garrigues,Yelena E Rubinchikova,C Michael Dipersio,Timothy M Rose
Journal of virology null
Regulation of trophoblast beta1-integrin expression by contact with endothelial cells
Thirkill, TL et al.
Cell communication and signaling : CCS, 2(1), 4-4 (2004)
V M Belkin et al.
The Journal of cell biology, 111(5 Pt 1), 2159-2170 (1990-11-01)
A membrane glycoprotein complex was isolated and purified from human smooth muscle by detergent solubilization and affinity chromatography on collagen-Sepharose. The complex was identified as VLA-1 integrin and consisted of two subunits of 195 and 130 kD in SDS-PAGE. Liposomes
V M Belkin et al.
Biochemistry and molecular biology international, 40(1), 53-60 (1996-09-01)
Integrins of the beta 1 family were isolated from human smooth muscle. SDS-PAGE analysis and subsequent immunoblotting demonstrated that integrin samples contain a protein immunologically related to beta 1 integrin subunit with the previously undescribed apparent molecular mass 205 kD.
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