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MILLIPLEX^® 犬细胞因子/趋化因子磁珠板 - 免疫学多重分析

Name: MILLIPLEX<SUP>®</SUP> 犬细胞因子/趋化因子磁珠板 - 免疫学多重分析
Brand: MM

Configurable Canine Cytokine/Chemokine 13-Plex Panel

别名:

canine interleukin immunoassay panel, luminex canine cytokine chemokine growth factor multiplex assay, luminex canine pro inflammatory anti inflammatory cytokine panel, millipore canine inflammation multiplex kit

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关于此项目

UNSPSC Code:

12161503

NACRES:

NA.47

eCl@ss:

32161000

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species reactivity

canine

Quality Level

200

assay range

accuracy: 91-109%, sensitivity: 13.6 pg/mL
(IFN-γ), sensitivity: 21.0 pg/mL
(MCP-1), sensitivity: 21.7 pg/mL
(IL-8), sensitivity: 3.2 pg/mL
(IP-10), sensitivity: 3.5 pg/mL
(IL-2), sensitivity: 3.7 pg/mL
(IL-6), sensitivity: 5.3 pg/mL
(KC-like), sensitivity: 5.8 pg/mL
(IL-18), sensitivity: 6.1 pg/mL
(TNFα), sensitivity: 7.5 pg/mL
(IL-7), sensitivity: 8.5 pg/mL
(IL-10), sensitivity: 9.0 pg/mL
(IL-15), sensitivity: 9.2 pg/mL
(GM-CSF), standard curve range: 12.2-50,000 pg/mL
(All analytes)

technique(s)

multiplexing: suitable

input

serum plasma (Cell culture, cell culture supernatants)

packaging

pkg of 1 ea

manufacturer/tradename

Milliplex^®

detection method

fluorometric (Luminex^® xMAP^® technology)

shipped in

wet ice

storage temp.

2-8°C

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General description

In addition to studying inflammation for dog nutrition and disease research, canine animal models are important for human biomedical research and drug development. Cytokine and chemokines are molecular mediators of immune cell response in inflammation and immunity. Quantification of cytokines and chemokines is essential to understanding the immune system, as well as for researching disease states such as autoimmune, allergic reactions, sepsis, and cancer.

Application

MILLIPLEX^® Qualified assays undergo rigorous assay development, verification, and Quality Control testing to achieve optimal performance. Simultaneously analyze up to 13 analytes in canine serum, plasma, and cell culture supernatants.

Analytes included: GM-CSF, IFNγ, IP-10, IL-2, IL-6, IL-7, IL-8, IL-10, IL-15, IL-18, KC-like, MCP-1, TNF-α

Assay Characteristics: Refer to kit protocol for assay cross-reactivity, sensitivity, precision, and accuracy.

Features and Benefits

通过在此面板中选择可用的分析物来设计多重试剂盒。

Legal Information

Luminex is a registered trademark of Luminex Corp

MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany

xMAP is a registered trademark of Luminex Corp

Disclaimer

For research use only. Not for use in diagnostic procedures.

Label License/Sticker for Assay Product:

By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.

pictograms

GHS08,GHS05,GHS07,GHS09

signalword

Danger

hcodes

H302 + H312 + H332,H317,H318,H373,H411

pcodes

P273 - P280 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338 - P314

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1 - STOT RE 2

target_organs

Respiratory Tract

存储类别

10 - Combustible liquids

wgk

WGK 3

法规信息

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Effect of immunosuppressive drugs on cytokine production in canine whole blood stimulated with lipopolysaccharide or a combination of ionomycin and phorbol 12-myristate 13-acetate.

Julien R S Dandrieux et al.

Veterinary medicine and science, 5(2), 199-205 (2019-01-22)

A pharmacodynamic assay has been previously developed to monitor ciclosporin treatment in dogs by assessing inhibition of cytokine transcription after whole blood stimulation with 12-myristate 13-1 acetate and ionomycin (PMA/I). In this study, whole blood stimulation with either PMA/I or

Association of Canine Osteosarcoma and Monocyte Phenotype and Chemotactic Function.

J L Tuohy et al.

Journal of veterinary internal medicine, 30(4), 1167-1178 (2016-06-25)

Monocytes/macrophages are likely key cells in immune modulation in dogs with osteosarcoma (OSA). Increased peripheral monocyte counts are negatively correlated with shorter disease-free intervals in dogs with OSA. Understanding the monocyte/macrophage's modulatory role in dogs with OSA can direct further

Intra-articular Administration of Allogeneic Adipose Derived MSCs Reduces Pain and Lameness in Dogs With Hip Osteoarthritis: A Double Blinded, Randomized, Placebo Controlled Pilot Study.

Chad B Maki et al.

Frontiers in veterinary science, 7, 570-570 (2020-10-29)

This study was conducted to investigate the therapeutic effect of allogeneic adipose-derived MSCs on dogs with hip osteoarthritis (OA). Twenty dogs with bilateral osteoarthritis of the coxofemoral (hip) joint, diagnosed by a veterinarian through physical examination and radiographs were randomly

Antimicrobial and anti-inflammatory thermo-reversible hydrogel for periodontal delivery.

Bing Wang et al.

Acta biomaterialia, 116, 259-267 (2020-09-17)

In periodontal treatment, topical adjunctive therapy with antimicrobials or anti-inflammatory agents is frequently applied. However, currently available drug carrier biomaterials often exhibit poor perfusion into small crevices, such as the deep and irregular periodontal pockets, due to relatively high viscosity.

Proinflammatory and Anti-Inflammatory Cytokines Mediated by NF-κB Factor as Prognostic Markers in Mammary Tumors.

Gustavo Rodrigues Martins et al.

Mediators of inflammation, 2016, 9512743-9512743 (2016-03-19)

Inflammation results in the production of cytokines, such as interleukin- (IL-) 4 and IL-10 with immunosuppressive properties or IL-6 and TNF-α with procarcinogenic activity. Furthermore, NF-κB is the major link between inflammation and tumorigenesis. This study verified the interaction between

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MILLIPLEX^® 犬细胞因子/趋化因子磁珠板 - 免疫学多重分析