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Merck
CN

CH2900010

亚叶酸 钙盐

Ph. Eur., USP

别名:

叶醛酸钙

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关于此项目

经验公式（希尔记法）:
C20H21CaN7O7
化学文摘社编号:
1492-18-8
分子量:
511.50
MDL number:
MFCD00006704
UNSPSC Code:
41116107

主要文件

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SMILES string

[Ca+2].[nH]1c2c([c](nc1N)=O)N(C(CN2)CNc3ccc(cc3)C(=O)N[C@@H](CCC(=O)[O-])C(=O)[O-])C=O

InChI

1S/C20H23N7O7.Ca/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30;/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32);/q;+2/p-2/t12?,13-;/m0./s1

InChI key

KVUAALJSMIVURS-ZEDZUCNESA-L

biological source

synthetic

grade

GMO free, GMP, Halal, Kosher

agency

Ph. Eur., USP

form

powder

application(s)

liquid formulation
pharmaceutical

storage temp.

2-8°C

Quality Level

600

General description

We provide industry-leading production know-how and comprehensive regulatory support for high-quality APIs, backed by nearly 200 years of experience. From a complete portfolio of innovative folates to custom synthesis, our customized and scalable solutions meet your specific production needs. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Calcium Folinate Hydrate amorphous has three main clinical applications:
1) First line treatment for colorectal cancer: In combination with the anticancer drug 5-fluorouracil (5-FU), Irinotecan, Cisplatin or Oxaliplatin, and its derivatives. Calcium Folinate is a modulator of 5-FU and enhances its efficacy in cancer chemotherapy.
2) Treatment of certain neoplastic diseases, severe psoriasis, and adult rheumatoid arthritis as a rescue therapy to reduce the toxic side effects of intermediate or high doses of methotrexate.
3) Treatment of anemia caused by folate deficiency.

Packaging

Customized packaging possible

Legal Information

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

存储类别

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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商品

Arcofolin® Methylfolate

Arcofolin® Methylfolate as a superior alternative to Folic Acid has uniquely become available for nutritional supplementation and fortification.

相关内容

Folate Vitamin B9

Our high-quality folates are manufactured under cGMP guideline ICH Q7 and backed by dedicated regulatory support worldwide.

叶酸（维生素B9）

我们的优质叶酸按照ICH Q7原料药cGMP标准生产,并提供专业的全球监管支持。

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

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