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Merck
CN

CH2900011

亚叶酸 钙盐

Ph. Eur., USP

别名:

叶醛酸钙

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关于此项目

经验公式（希尔记法）:
C20H21CaN7O7
化学文摘社编号:
1492-18-8
分子量:
511.50
MDL number:
MFCD00006704
UNSPSC Code:
41116107

主要文件

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产品名称

亚叶酸 钙盐, Ph. Eur., USP

SMILES string

[Ca+2].[nH]1c2c([c](nc1N)=O)N(C(CN2)CNc3ccc(cc3)C(=O)N[C@@H](CCC(=O)[O-])C(=O)[O-])C=O

InChI

1S/C20H23N7O7.Ca/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30;/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32);/q;+2/p-2/t12?,13-;/m0./s1

InChI key

KVUAALJSMIVURS-ZEDZUCNESA-L

biological source

synthetic

grade

GMO free
GMP
Halal
Kosher

agency

Ph. Eur.
USP

form

powder

application(s)

pharmaceutical
solid formulation

storage temp.

2-8°C

Quality Level

600

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Application

Calcium Folinate Hydrate crystalline has three main clinical applications:
1) First line treatment for colorectal cancer: In combination with the anticancer drug 5-fluorouracil (5-FU), Irinotecan, Cisplatin or Oxaliplatin, and its derivatives. Calcium Folinate is a modulator of 5-FU and enhances its efficacy in cancer chemotherapy.
2) Treatment of certain neoplastic diseases, severe psoriasis, and adult rheumatoid arthritis as a rescue therapy to reduce the toxic side effects of intermediate or high doses of methotrexate.
3) Treatment of anemia caused by folate deficiency.

General description

We provide industry-leading production know-how and comprehensive regulatory support for high-quality APIs, backed by nearly 200 years of experience. From a complete portfolio of innovative folates to custom synthesis, our customized and scalable solutions meet your specific production needs. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Packaging

Customized packaging possible

Legal Information

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

存储类别

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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商品

Arcofolin® Methylfolate

Arcofolin® Methylfolate as a superior alternative to Folic Acid has uniquely become available for nutritional supplementation and fortification.

相关内容

Folate Vitamin B9

Our high-quality folates are manufactured under cGMP guideline ICH Q7 and backed by dedicated regulatory support worldwide.

叶酸（维生素B9）

我们的优质叶酸按照ICH Q7原料药cGMP标准生产,并提供专业的全球监管支持。

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

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