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Merck
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CKT1MAG-97K

MILLIPLEX® Canine Kidney Toxicity Panel

Configurable Canine Kidney Toxicity Expanded 7-Plex Panel 1

别名:

canine nephropathy markers, canine renal health panel, chemokine signaling analytes, dog serum and urine profiling, fibrosis-related markers, glomerular filtration indicators, immune response proteins, kidney inflammation panel, renal injury biomarkers, tubular damage proteins

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UNSPSC Code:
12161503
NACRES:
NA.84
eCl@ss:
32161000

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产品名称

MILLIPLEX® Canine Kidney Toxicity Panel,

species reactivity

canine

Quality Level

200

description

Configurable Canine Kidney Toxicity Expanded 7-Plex Panel 1

assay range

accuracy: 89-107%, sensitivity: 0.005-0.630 ng/mL
(All other analytes; MinDC +2SD), sensitivity: 0.670 pg/mL
(KIM-1; MinDC +2SD), standard curve range: 0.01-10 ng/mL
(Cystatin C), standard curve range: 0.01-10 ng/mL
(Osteopontin), standard curve range: 0.03-20 ng/mL
(Lipocalin-2/NGAL), standard curve range: 0.07-50 ng/mL
(IL-8), standard curve range: 0.07-50 ng/mL
(MCP-1), standard curve range: 1.0-700 pg/mL
(KIM-1), standard curve range: 1.4-1,000 ng/mL
(Clusterin)

technique(s)

multiplexing: suitable

input

urine

packaging

pkg of 1 ea

manufacturer/tradename

Milliplex®

detection method

fluorometric (Luminex® xMAP® technology)

shipped in

wet ice

storage temp.

2-8°C

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General description

Kidney injury in dogs involves complex inflammatory and cellular responses, reflected in biomarkers such as Clusterin, Cystatin C, IL-8 (CXCL8), KIM-1, MCP-1 (CCL2), NGAL (Lipocalin-2), and Osteopontin (OPN). Clusterin is a stress-induced protein linked to tissue protection and repair. Cystatin C reflects glomerular filtration efficiency. IL-8 and MCP-1 are chemokines involved in immune cell recruitment during inflammation. KIM-1 and NGAL are sensitive indicators of tubular damage, while OPN plays a role in fibrosis and immune modulation. Together, these analytes provide a comprehensive profile of renal injury, inflammation, and recovery in canine models

Application

MILLIPLEX® Qualified assays undergo rigorous assay development, verification, and Quality Control testing to achieve optimal performance. Simultaneously analyze up to 7 analytes in canine urine samples.

Analytes included: Clusterin, Cystatin C, IL-8 (CXCL8), KIM-1, MCP-1 (CCL2), NGAL (Lipocalin-2), Osteopontin (OPN)

Assay Characteristics: Refer to assay protocol for details on cross-reactivity, sensitivity, precision, and accuracy.

Features and Benefits

Features:
  • Targets key biomarkers of renal injury, inflammation, and tissue remodeling
  • Includes 7 analytes covering glomerular filtration, tubular damage, chemokine signaling, and fibrosis
  • Multiplex format enables simultaneous detection from minimal sample volume
  • Compatible with canine serum, plasma, and urine samples
  • Designed for kidney toxicity, nephropathy, and renal recovery research in dogs
Benefits:
  • Provides a detailed molecular profile of kidney damage and repair mechanisms
  • Supports evaluation of therapeutic interventions targeting renal inflammation and fibrosis
  • Facilitates monitoring of acute and chronic kidney injury in preclinical canine models
  • Enhances understanding of immune cell recruitment and tubular stress responses
  • Streamlines experimental workflows with high-throughput, multi-analyte capability

Legal Information

Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp

Disclaimer

For research use only. Not for use in diagnostic procedures.

Label License/Sticker for Assay Product:

By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1 - STOT RE 2

target_organs

Respiratory Tract

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

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Alvaro Felipe de Lima Ruy Dias et al.
Veterinary world, 13(8), 1620-1626 (2020-10-17)
Canine visceral leishmaniasis (CanL) has a broad spectrum of changes, with kidney disease being considered the main cause of mortality. Thus, this study aimed to monitor serum and urinary biomarkers in response to two short-term treatments for CanL. Thirty dogs

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