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Merck
CN

DX1726

Supelco

N,N-二甲基甲酰胺

OmniSolv®

别名:

DMF, NSC 5356

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关于此项目

线性分子式:
HCON(CH3)2
化学文摘社编号:
分子量:
73.09
Beilstein:
605365
MDL编号:
UNSPSC代码:
12352111
EC索引号:
200-679-5
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蒸汽密度

2.5 (vs air)

质量水平

蒸汽压

2.7 mmHg ( 20 °C)

产品线

OmniSolv®

方案

≥99.9% (GC)

表单

liquid

自燃温度

833 °F

保质期

24 mo.

expl. lim.

15.2 %

技术

HPLC: suitable
LC/MS: suitable
gas chromatography (GC): suitable

杂质

<0.05% Water

蒸发残留物

<5 ppm

颜色

APHA: 10

折射率

n20/D 1.430 (lit.)

pH值(酸碱度)

7 (20 °C, 200 g/L in H2O)

沸点

153 °C (lit.)

mp

−61 °C (lit.)

转变温度

flash point 57.5 °C

密度

0.944 g/mL (lit.)

UV cutoff

≤268 nm

紫外吸收

λ: 268 nm Amax: ≤1.00
λ: 270 nm Amax: ≤0.75
λ: 275 nm Amax: ≤0.30
λ: 295 nm Amax: ≤0.07
λ: 310 nm Amax: ≤0.03
λ: 340 nm Amax: ≤0.01

运输

ambient

储存温度

room temp

SMILES字符串

[H]C(=O)N(C)C

InChI

1S/C3H7NO/c1-4(2)3-5/h3H,1-2H3

InChI key

ZMXDDKWLCZADIW-UHFFFAOYSA-N

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一般描述

N,N - Dimethylformamide (DMF) is a highly effective polar aprotic solvent for a wide range of compounds. This is due to its ability to interact effectively with different compounds. DMF can function as both an electrophilic and nucleophilic agent, and it can provide various key intermediates that mediate chemical reactions.

应用

多种疏水性有机化合物的溶剂。
N,N-Dimethylformamide (DMF) is used

  • As a solvent in the Wittig reaction for synthesizing α-hydroxy amides.
  • In the preparation of the Vilsmeier reagent when treated with phosphorus oxychloride or other acid chlorides, which is utilized for formylating, halogenating, and dehydroxylating reactions.
  • As a solvent in the synthesis of alkyl halides from alcohols.
  • As a co-solvent to examine the relationship between medium polarity and drug solubility.
OmniSolv®

包装

M-Bottle for Solvents
As a global leader in lab reagents, we are constantly looking for new ways to optimize the safety of our products. The newly developed 4L solvent bottle design features advanced sealing technology that eliminates leaks to make the handling of solvents safer and more convenient than ever before.
See all the new features here!
is packaged in 1L amber glass bottle
is packaged in 4L amber glass bottle
is packaged in 4L polycoated glass bottle

制备说明

Product filtered through a 0.2 μm filter

分析说明

Assay (GC): 99.9% min
Color (APHA): 10 max
Evaporation residue: 5ppm max
Expiration date: 24 months
Filtered through 0.2 m filter: To pass test
Form: Clear liquid
Infrared Spectrum: Conforms to standard
Titrable acid: eq/g
Titrable base: eq/g
UV Abs. at 268 nm: 1.00AU max
UV Abs. at 270 nm: 0.75AU max
UV Abs. at 275 nm: 0.30AU max
UV Abs. at 295 nm: 0.07AU max
UV Abs. at 310 nm: 0.03AU max
UV Abs. at 340 nm: 0.01AU max
UV Cut-off: 268nm max
Water (H2O): 0.05% max

法律信息

OMNISOLV is a registered trademark of Merck KGaA, Darmstadt, Germany

警示用语:

Danger

危险分类

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Eye Irrit. 2 - Flam. Liq. 3 - Repr. 1B

储存分类代码

3 - Flammable liquids

WGK

WGK 2

闪点(°F)

135.5 °F - closed cup

闪点(°C)

57.5 °C - closed cup

法规信息

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Phenformin in aqueous co-solvent mixtures of N, N-dimethylformamide, ethanol, N-methylpyrrolidone and dimethyl sulfoxide: Solubility, solvent effect and preferential solvation
Zhao, Xi and Farajtabar, et. al.
The Journal of Chemical Thermodynamics, 144, 106085-106085 (2020)
N, N-Dimethylformamide: much more than a solvent
Muzart, Jacques
Tetrahedron, 65, 8313-8323 (2009)
N, N-Dimethylformamide
Comins, Daniel L and Joseph, Sajan P
Encyclopedia of Reagents for Organic Synthesis, Second Edition (2001)
Formation of poly (vinylidene fluoride) crystalline phases from tetrahydrofuran/N, N-dimethylformamide mixed solvent}
Ma, Wenzhong and Zhang, Jun and Wang, Xiaolin
Journal of Materials Science, 43, 398-401 (2008)

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