一般描述
Chymostatin. M.W. 604.92
Mixture of types A, B and C. Inhibits Chymotrypsin-like serine proteases including alpha, beta, gamma and delta chymotrtrypsins.
Sequence:
[(S)-1-Carboxy-2-Phenylethyl]-Carbamoyl-a-[2-Iminohexahydro-4(S)-Pyrimidyl]-(S)-Glycyl-X-Phenylalaninal
X: L-Leu (type A), L-Ile (type B), L-Val (type C)
Working concentrations 10-100μM.
Stable for several hours. Soluble in DMSO and glacial acetic acid. Solutions are stable for a month at -20ºC.
5mg/825 microliters in DMSO = 10mM solution.
Dilute 1:100 for 100μM working solution.
Mixture of types A, B and C. Inhibits Chymotrypsin-like serine proteases including alpha, beta, gamma and delta chymotrtrypsins.
Sequence:
[(S)-1-Carboxy-2-Phenylethyl]-Carbamoyl-a-[2-Iminohexahydro-4(S)-Pyrimidyl]-(S)-Glycyl-X-Phenylalaninal
X: L-Leu (type A), L-Ile (type B), L-Val (type C)
Working concentrations 10-100μM.
Stable for several hours. Soluble in DMSO and glacial acetic acid. Solutions are stable for a month at -20ºC.
5mg/825 microliters in DMSO = 10mM solution.
Dilute 1:100 for 100μM working solution.
生化/生理作用
Inhibitor Type: Protease Inhibitors
外形
Lyophilized. Dissolve in dimethylsulfoxide (DMSO). After powder is thoroughly dissolved, dilute the DMSO solution with 0.9% NaCl. The concentration of DMSO should be maintained at 10% or higher. Otherwise chymostatin may precipitate from the solution.
Example: Reconstitute 1 mg of chymostatin with 1.65 mL of DMSO. Then add 14.85 mL of 0.9% NaCl. This furnishes a 10-4 M solution. No preservatives added.
Example: Reconstitute 1 mg of chymostatin with 1.65 mL of DMSO. Then add 14.85 mL of 0.9% NaCl. This furnishes a 10-4 M solution. No preservatives added.
制备说明
Maintain lyophilized material at -20ºC for up to one year. Store reconstituted product in aliquots at -20ºC for up to 3-4 weeks. Do not thaw and refreeze.
法律信息
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Chymostatin, a new chymotrypsin inhibitor produced by actinomycetes.
H Umezawa et al.
The Journal of antibiotics, 23(8), 425-427 (1970-08-01)
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