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Merck
CN

EZHGIP

Millipore

Human GIP ELISA Kit

measures and quantify total GIP levels in 20 μL serum, plasma or cell culture samples

别名:

Gastric inhibitory polypeptide, Glucose-dependent insulinotropic polypeptide, Incretin hormone

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关于此项目

UNSPSC代码:
12161503
eCl@ss:
32161000
NACRES:
NA.32

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产品名称

人GIP（总）ELISA, This Human GIP (total) ELISA is used to measure & quantify GIP levels in Metabolism & Endocrine research.

质量水平

200

种属反应性

human

包装

kit of 1 × 96 wells

参数

20 μL sample volume (4hr assay)

assay range

accuracy: 86.7%
linearity: 99.9%
sensitivity: 8.2 pg/mL
standard curve range: 8.2-2000 pg/mL

技术

ELISA: suitable

输入

sample type cell culture supernatant
sample type serum
sample type plasma (K2 EDTA)

NCBI登记号

NM_002070.2

UniProt登记号

P04899

应用

research use

检测方法

colorimetric (450nm/590nm)

运输

wet ice

储存温度

2-8°C

基因信息

human ... GNAI2(2771)

相关类别

一般描述

GIP也称抑胃肽或葡萄糖依赖性促胰岛素多肽，由位于人染色体17q12-q21的基因编码。它是由K 细胞在肠上皮中合成和分泌。胃肠道的GIP 分泌在葡萄糖糖稳态中起重要作用。 它在口服摄入营养素后刺激胰腺β细胞分泌胰岛素。此外，GIP 也促进胰岛素的生物合成和β-细胞增殖，并减缓β-细胞凋亡。GIP还通过刺激脂肪细胞中甘油三酯合成促进脂肪代谢。 GIP水平上升可导致肥胖和高胰岛素血症。该人GIP（总计）ELISA用于测量 & 定量代谢 & 内分泌研究中的GIP水平。

应用

人GIP（总）ELISA已用于测定血样中的总葡萄糖依赖性促胰岛素多肽（GIP）。

其他说明

研究亚类 肥胖 代谢疾病 室温，3.5 小时，,20 µL 样品体积，血清，血浆或组织培养基 研究类别 代谢

免责声明

仅供研究使用。不用于诊断操作。

警示用语：

Danger

危险分类

Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Met. Corr. 1 - Skin Sens. 1

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

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L A Anderson et al.
Genomics, 17(3), 618-623 (1993-09-01)
To facilitate the positional cloning of the breast-ovarian cancer gene BRCA1, we constructed a high-density genetic map of the 8.3-cM interval between D17S250 and GIP on chromosome 17q12-q21. Markers were mapped by linkage in the CEPH and in extended kindreds
Frank Isken et al.
American journal of physiology. Endocrinology and metabolism, 295(2), E350-E355 (2008-05-29)
Menopause and premature gonadal steroid deficiency are associated with increases in fat mass and body weight. Ovariectomized (OVX) mice also show reduced locomotor activity. Glucose-dependent-insulinotropic-polypeptide (GIP) is known to play an important role both in fat metabolism and locomotor activity.
Dietary sugars stimulate fatty acid synthesis in adults.
Elizabeth J Parks, Lauren E Skokan, Maureen T Timlin, Carlus S Dingfelder
The Journal of Nutrition null
Aya Maeda et al.
Journal of diabetes investigation, 4(3), 281-286 (2014-05-21)
Incretins might play some pathophysiological role in glucose metabolism in diabetes and obesity; it is not clear whether or not the amount and the pattern of incretin secretion vary with different types of sugars. To evaluate the effect of two
Tsuyoshi Yanagimachi et al.
Molecular metabolism, 6(2), 226-231 (2017-02-10)
Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) possess multiple bioactive isoforms that are rendered non-insulinotropic by the enzyme dipeptidyl peptidase-4 (DPP-4). Recently, some ELISA kits have been developed to specifically measure "active" GIP and GLP-1, but it is unclear
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