产品名称
High Sensitivity Human Amyloid β42 ELISA, This High Sensitivity Human Amyloid β42 ELISA is used to measure & quantify Amyloid β42 levels in Neuroscience research.
species reactivity
human
packaging
kit of 1 × 96 wells
parameter
50 μL sample volume (Overnight assay)
assay range
sensitivity: 8.0 pg/mL
(50 μl sample size)
standard curve range: 16-500 pg/mL
technique(s)
ELISA: suitable
input
sample type plasma (K2 EDTA)
sample type serum
sample type cerebrospinal fluid (CSF)
application(s)
research use
detection method
colorimetric (450nm/590nm)
shipped in
wet ice
storage temp.
2-8°C
Quality Level
Gene Information
human ... APP(351)
Application
Used to detect/quantify: Amyloid β42
Research Category
Neuroscience
Neuroscience
Research Sub Category
Alzheimer′s Disease
Alzheimer′s Disease
This High Sensitivity Human Amyloid β42 ELISA is used to measure & quantify Amyloid β42 levels in Neuroscience research.
This assay requires 50 µl of sample and is an overnight assay.
Biochem/physiol Actions
The Amyloid β42 ELISA (HS) uses monoclonal anti-Aβ antibodies with high selectivity for human Aβ. The capture antibody recognizes the C-terminal end of Amyloid β1-42, which causes a high selectivity for Aβ42. The cross-reactivity of the used antibodies to other Amyloid peptides was tested by ELISA and BIACORE and shows no significant cross-reactivity to Aβ1-38, Aβ1-39, Aβ1-40, Aβ1-43 and Aβ1-44.
Disclaimer
For research use only. Not for use in diagnostic procedures.
General description
Amyloid beta peptides have been implicated in the etiology of Alzheimer’s disease. Amyloid beta 40 is the most prominent peptide and Amyloid beta 42 is the neurotoxic form. The Amyloid beta 42/40-ratio (AB ratio) has been reported as a better indicator of the Alzheimer pathology. Millipore’s High Sensitivity Human Amyloid β42 ELISA kit is used for the measurement of Amyloid β42 in cerebrospinal fluid, cell culture supernatants, primary neurons and plasma in a 96-well format.
Other Notes
Please contact Technical Service for linearity of dilution.
Preparation Note
Components in the kit can be stored up to 2 weeks at 2-8°C
signalword
Warning
hcodes
Hazard Classifications
Aquatic Chronic 3 - Met. Corr. 1 - Skin Sens. 1
存储类别
8A - Combustible corrosive hazardous materials
法规信息
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Teresa Niccoli et al.
Current biology : CB, 26(17), 2291-2300 (2016-08-16)
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Journal of Alzheimer's disease : JAD, 44(4), 1263-1278 (2014-11-20)
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Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology, 33(1), 13-18 (2014-05-21)
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