Milli-Mark^® Anti-CD23-FITC Antibody, clone MHM6

Control
human lymphocytes

Evaluated by flow cytometry using human lymphocytes.

Detect CD23 using this Milli-Mark Anti-CD23-FITC Antibody, clone MHM6 validated for use in FC.

Research Category
Inflammation & Immunology

Research Sub Category
Immunoglobulins & Immunology

Antibody recognizes Human CD23 antigen.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

45 kDa (Kikutani, 1987; Aubry, 1987)

CD23 is a 45 kDa type II membrane glycoprotein belonging to the C-type lectin family, and is identical to the low affinity IgE receptor (FceRII) (Kikutani, 1987; Aubry, 1987). CD23 is primarily expressed on B cells and monocytes including a strong expression on EBV-transformed B lymphoblasts (Sarfati, 1997; Sarfati, 1995). CD23 is also present on a large variety of other cells such as T cells, eosinophils, platelets, Langerhans cells, and a subset of thymic epithelial cells (Sarfati, 1995). However, CD23 is absent in a large number of normal non-lymphoid human tissues, such as, central nervous system, endocrine glands, gastrointestinal, respiratory, urinary, and female/male reproductive system, skin, bone, cartilage, connective tissue, muscles, peripheral nerves, vessels, mesothelium, synovium, placenta, and umbilical cord (Pallesen, 1987). Anti-CD23, MHM6, was included in the Second, Third, Fourth, and Fifth International Workshop and Conference on Human Leukocyte Differentiation Antigens, and studies by a number of laboratories confirmed its reactivity with CD23 (Sarfati, 1995).

EBV-transformed B-lymphoblastoid cells

Protein A purified

Purified Mouse monoclonal IgG1 conjugated to FITC in 0.05M Tris-HCl buffer with 1% BSA, Sodium Azide at 0.097% at pH 7.2.

Maintain refrigerated at 2-8°C protected from light in undiluted aliquots for up to 6 months from date of receipt.

MILLI-MARK is a registered trademark of Merck KGaA, Darmstadt, Germany