FCMAB389F
Milli-Mark® Anti-Integrin β1-FITC Antibody, activated, clone HUTS-4
clone HUTS-4, Milli-Mark®, from mouse
别名:
Ligand-induced Binding Site, LIBS, CLIBS
产品名称
Milli-Mark® Anti-Integrin β1-FITC Antibody, activated, clone HUTS-4, clone HUTS-4, Milli-Mark®, from mouse
biological source
mouse
conjugate
FITC conjugate
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
HUTS-4, monoclonal
species reactivity
human
manufacturer/tradename
Milli-Mark®
technique(s)
flow cytometry: suitable
isotype
IgG2b
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... ITGB1(3688)
Analysis Note
Evaluated by flow cytometry using A431 cells.
Application
Milli-Mark Anti-Integrin β1-FITC Antibody, activated, clone HUTS-4 is an antibody against Integrin β1 for use in FC.
General description
88 kDa Calculated
Integrin beta 1, also known as CD29, is a 130 kDa transmembrane glycoprotein that forms noncovalent complexes with various Integrin alpha subunits 1 to 6 (CD49a to CD49f) also known as Very Late Antigens (VLA). CD29 is also called platelet GPIIa. The antigen mediates cellular adhesion and has broad cellular reactivity, but is not expressed by erythrocytes. In normal peripheral blood it is found on a subset of CD4+ and CD8+ T lymphocytes and on a minority of B lymphocytes. The "inducer" subpopulation of CD4+ lymphocytes co-express CD4 and CD29.
Other Notes
Unconjugated antibody Cat. No. MAB2079Z is known to react with Rat.
Legal Information
MILLI-MARK is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
J Meller et al.
Journal of thrombosis and haemostasis : JTH, 10(7), 1397-1408 (2012-05-09)
Kindlin-3 is a novel integrin activator in hematopoietic cells, and its deficiency leads to immune problems and severe bleeding, known as leukocyte adhesion deficiency III (LAD-III). Our current understanding of Kindlin-3 function primarily relies on analysis of animal models or
Dwayne A L Vickers et al.
PloS one, 8(6), e65828-e65828 (2013-06-14)
Adhesion-based microfluidic cell separation has proven to be very useful in applications ranging from cancer diagnostics to tissue engineering. This process involves functionalizing microchannel surfaces with a capture molecule. High specificity and purity capture can be achieved using this method.
Marleen Leidecker et al.
Microbiology spectrum, 11(3), e0388622-e0388622 (2023-03-31)
Invasion of host cells is an important feature of Staphylococcus aureus. The main internalization pathway involves binding of the bacteria to host cells, e.g., endothelial cells, via a fibronectin (Fn) bridge between S. aureus Fn binding proteins and α5β1-integrin, followed
Dasom Shin et al.
Nature communications, 15(1), 2789-2789 (2024-03-31)
Proprotein convertase subtilisin/kexin type-9 (PCSK9) binds to and degrades low-density lipoprotein (LDL) receptor, leading to increase of LDL cholesterol in blood. Its blockers have emerged as promising therapeutics for cardiovascular diseases. Here we show that PCSK9 itself directly induces inflammation
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