FUNCTION: SwissProt: P10147 # Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV).
SIZE: 92 amino acids; 10085 Da
SUBUNIT: Self-associates. Also heterodimer of MIP-1-alpha(4-69) and MIP-1-beta(3-69).
SUBCELLULAR LOCATION: Secreted.
PTM: N-terminal processed form LD78-alpha(4-69) is produced by proteolytic cleavage after secretion from HTLV1-transformed T- cells.
SIMILARITY: SwissProt: P10147 ## Belongs to the intercrine beta (chemokine CC) family.

GF048 produces chemotaxis over a wide concentration range in an assay using rat peritoneal macrophages. Significant chemotaxis was achieved using a concentration of 50-100 ng/mL.

Lyophilized powder with no additives.

The lyophilized powder, though stable at room temperature, is best stored at -20°C. Reconstitute in water to a concentration of 0.1-1.0 mg/mL. Further dilutions can be made into other aqueous buffers and stored at 2-8 °C for 1 week or -20 °C for future use. Reconstituted rat MIP-1alpha should be stored in undiluted aliquots at -20°C for up to 6 months.

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