GF314
不含人重组动物的TNF- α蛋白
Tumor necrosis factor alpha (TNF-α), also known as cachectin & TNFSF1A, is the prototypic ligand of the TNF superfamily. Recombinant animal free human TNF-α is manufactured using all non-animal reagents.
别名:
Tumor Necrosis Factor Alpha, TNFa, TNF-alpha, Cachectin, TNFSF1A
重组
expressed in E. coli
质量水平
方案
>98% (SDS-PAGE and HPLC)
杂质
<0.1 μg/mg protein endotoxin (<1EU/μg)
NCBI登记号
UniProt登记号
运输
dry ice
相关类别
一般描述
产品来源：大肠埃希菌
肿瘤坏死因子α（TNF-α），又称恶病质素或TNFSF1A，是TNF超家族的原型配体。它是一种多效性分子，在炎症、凋亡和免疫系统发育中起核心作用。TNF-α是由多种免疫细胞和上皮细胞产生的。 它属于TNF配体家族，通过TNFR1和TNFR2两个受体进行信号传导。TNF-α对多种肿瘤细胞具有细胞毒性，是介导免疫反应对抗细菌感染的重要因子。TNF-α在感染性休克、自身免疫性疾病、类风湿性关节炎、炎症和糖尿病的诱导中也起作用。重组人TNF-α是一种可溶性157个氨基酸的蛋白质（17.4 kDa），对应于全长跨膜蛋白的C末端胞外域。
应用
研究子范畴
生长因子 & 受体
生长因子 & 受体
研究类别
炎症 & 免疫学
炎症 & 免疫学
生化/生理作用
交叉反应
牛、猴、小鼠、大鼠、羊
牛、猴、小鼠、大鼠、羊
外形
冻干前，采用0.2 μm过滤器过滤产品。
无动物成分重组人TNF- α是使用所有非动物试剂制备的。
制备说明
自收货之日起，在-20°C下最多保存6个月。
分析说明
生物活性测定：通过放线菌素D对小鼠L929细胞的细胞溶解测定ED50为≤ 0.05 ng/ml，对应的比活性为 ≥2 x 107单位/mg。
免责声明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
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