MILLIPLEX^® Human Cardiovascular Disease Panel

Cross Reactivty
There was no or negligible cross-reactivity between the antibodies for an analyte and any of the other analytes in this panel.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

For research use only. Not for use in diagnostic procedures.Label License/Sticker for Assay Product:By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.

For research use only. Not for use in diagnostic procedures.Label License/Sticker for Assay Product:By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.

For research use only. Not for use in diagnostic procedures.Label License/Sticker for Assay Product:By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.

Cardiovascular disease, particularly atherosclerotic vascular disease, is a leading cause of global mortality, accounting for 30% of all global deaths (WHO, 2010). Inflammatory mechanisms play a vital role in the initiation, maintenance, and progression of vascular disease with a strong correlation between inflammatory markers and prognosis in acute and chronic coronary artery disease. Numerous studies have demonstrated an association of obesity and diabetes with cardiovascular risk factors.

MILLIPLEX^® Human Cardiovascular Disease (CVD) Panel 4 is an 7-plex kit to be used for the simultaneous quantification of any or all of the following analytes in human serum, plasma or tissue/cell lysate and culture supernatant samples: sE-Selectin, Follistatin (FST), Pecam-1, Pentraxin-3 (PTX-3), Tissue Factor (TF), Thrombomodulin, and Troponin T. This kit uses a 96-well format, contains a lyophilized standard cocktail, two internal assay quality controls and can measure up to 38 samples in duplicate.

The Luminex^® xMAP^® platform uses a magnetic bead immunoassay format for ideal speed and sensitivity to quantitate multiple analytes simultaneously, dramatically improving productivity while conserving valuable sample volume.

Panel Type: Cardiovascular

Endothelial dysfunction and vascular inflammation are central to the development and progression of cardiovascular disease. This set of biomarkers—sCD31/sPECAM-1, sE-Selectin, Follistatin (FST), Pentraxin-3 (PTX3), Thrombomodulin, Tissue Factor (TF), and Troponin T (TnT)—captures key indicators of endothelial activation, coagulation, and cardiac injury. These analytes are valuable for studying vascular remodeling, atherosclerosis, and acute coronary syndromes, supporting both translational and clinical cardiovascular research.

Sensitivity: See kit protocol for individual analytes sensitive’s.

Luminex is a registered trademark of Luminex Corp

MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany

xMAP is a registered trademark of Luminex Corp

MILLIPLEX^® Qualified assays undergo rigorous assay development, verification, and Quality Control testing to achieve optimal performance. Simultaneously analyze up to 7 analytes in human serum, plasma, or cell culture supernatants.Analytes included: sCD31/sPECAM-1, sE-Selectin, Follistatin (FST), Pentraxin-3 (PTX3), Thrombomodulin, Tissue Factor (TF), Troponin T (TnT)Assay Characteristics: Refer to assay protocol for details on cross-reactivity, sensitivity, precision, and accuracy.

Features:

• Targets biomarkers involved in endothelial activation, coagulation, and cardiac injury
• Includes 7 analytes relevant to vascular health, inflammation, and myocardial damage
• Multiplex format enables simultaneous detection from minimal sample volume
• Compatible with human serum and plasma samples
• Designed for research in cardiovascular disease, thrombosis, and vascular inflammation

Benefits:

• Provides a focused profile of vascular and cardiac biomarkers
• Supports investigation of endothelial dysfunction and myocardial injury mechanisms
• Facilitates evaluation of therapeutic interventions and cardiovascular risk assessment
• Enables high-throughput analysis with reduced sample and reagent use
• Delivers reproducible, sensitive results for translational and clinical research