HCYP3MAG-63K
MILLIPLEX® 人细胞因子/趋化因子磁珠板III - 免疫学多重分析
Configurable Human Cytokine/Chemokine 11-Plex Panel 3
别名:
Human cytokine multiplex kit, Luminex® human cytokine immunoassay, Millipore human cytokine panel
产品名称
MILLIPLEX® 人细胞因子/趋化因子磁珠板III - 免疫学多重分析,
species reactivity
human
Quality Level
description
Configurable Human Cytokine/Chemokine 11-Plex Panel 3
packaging
pkg of 1 ea
manufacturer/tradename
Milliplex®
assay range
accuracy: 92-106%, standard curve range: 2.0-200,000 pg/mL
technique(s)
multiplexing: suitable
input
cell culture supernatant
serum
detection method
fluorometric (Luminex® xMAP® technology)
shipped in
wet ice
storage temp.
2-8°C
General description
Cytokines are versatile signaling molecules that regulate immune cell communication, inflammation, and tissue homeostasis. In metabolic and autoimmune disorders, dysregulated cytokine networks drive chronic inflammation, insulin resistance, and tissue damage. Chemokines, a subset of cytokines, direct immune cell migration to sites of injury or infection, while growth factors like M-CSF modulate cell proliferation and repair. In obesity, pro-inflammatory cytokines exacerbate adipose tissue dysfunction, whereas in autoimmune diseases, they promote aberrant immune activation against self-tissues. Conversely, anti-inflammatory cytokines work to restore equilibrium, highlighting their dual role as both drivers of pathology and potential therapeutic targets. Understanding these dynamic interactions is key to developing interventions for conditions ranging from IBD to metabolic syndrome.
Application
MILLIPLEX® Qualified assays undergo rigorous assay development, verification, and Quality Control testing to achieve optimal performance. Simultaneously analyze up to 11 analytes in human serum, plasma, and cell culture supernatants.
Analytes included: GCP2, HCC-1, I-TAC, IL-11, IL-29, Lymphotactin, M-CSF, MIG, MIP-3α, MIP-3α, NAP2
Note: HCC-1/CCL14a and NAP-2/CXCL7 cannot be plexed with other analytes for serum/plasma.
Assay Characteristics: Refer to kit protocol for assay cross-reactivity, sensitivity, precision, and accuracy.
Analytes included: GCP2, HCC-1, I-TAC, IL-11, IL-29, Lymphotactin, M-CSF, MIG, MIP-3α, MIP-3α, NAP2
Note: HCC-1/CCL14a and NAP-2/CXCL7 cannot be plexed with other analytes for serum/plasma.
Assay Characteristics: Refer to kit protocol for assay cross-reactivity, sensitivity, precision, and accuracy.
Features and Benefits
- Targeted Multiplex Profiling: Simultaneously quantify 11 cytokines/chemokines (e.g., MIP-3, IL-29, M-CSF) linked to metabolic disorders, obesity, and autoimmune mechanisms, enabling focused study of immune-inflammatory pathways.
- Luminex xMAP Technology: Magnetic bead-based multiplexing ensures high sensitivity and throughput with minimal sample volume (serum, plasma, or culture supernatants).
- Configure Your Panel: Select specific analytes (e.g., I-TAC, Lymphotactin) to tailor assays to your research needs, reducing costs and optimizing efficiency.
- Optimized Sample Dilutions: Run most analytes neat (except NAP-2 and HCC-1, requiring 1:100 dilution for serum/plasma), simplifying workflow for diverse sample types.
- Accelerate Translational Insights: Investigate chemokine networks in metabolic syndrome or autoimmune diseases and uncover therapeutic targets (e.g., IL-29 in viral responses, M-CSF in macrophage activation).
Legal Information
Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp
Disclaimer
For research use only. Not for use in diagnostic procedures.
Label License/Sticker for Assay Product:
By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.
Label License/Sticker for Assay Product:
By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.
signalword
Danger
target_organs
Respiratory Tract
存储类别
10 - Combustible liquids
wgk
WGK 3
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT RE 2
法规信息
新产品
此项目有
Kristen M Reeder et al.
Mucosal immunology, 11(5), 1352-1362 (2018-06-17)
Asthmatics sensitized to fungi are reported to have more severe asthma, yet the immunopathogenic pathways contributing to this severity have not been identified. In a pilot assessment of human asthmatics, those subjects sensitized to fungi demonstrated elevated levels of the
Marie L Landry et al.
The Journal of infectious diseases, 217(6), 897-905 (2017-12-28)
Despite the high burden of respiratory infection and the importance of early and accurate diagnosis, there is no simple diagnostic test to rule in viral infection as a cause of respiratory symptoms. We performed RNA sequencing on human nasal epithelial
Alice L den Hertog et al.
PloS one, 10(6), e0129552-e0129552 (2015-06-27)
Many patients treated for tuberculosis (TB) in low and middle income countries are treated based on clinical suspicion without bacteriological confirmation. This is often due to lack of rapid simple accurate diagnostics and low healthcare provider confidence in the predictive
Matthew S Godwin et al.
American journal of physiology. Lung cellular and molecular physiology, 320(3), L393-L404 (2020-12-17)
Individuals that present with difficult-to-control asthma and sensitivity to one or more fungal species are categorized as a subset of severe asthma patients belonging to a group herein referred to as severe asthma with fungal sensitization (SAFS). We have previously
Junru Wu et al.
Cell reports. Medicine, 2(12), 100478-100478 (2022-01-15)
Trauma is a leading cause of death and morbidity worldwide. Here, we present the analysis of a longitudinal multi-omic dataset comprising clinical, cytokine, endotheliopathy biomarker, lipidome, metabolome, and proteome data from severely injured humans. A "systemic storm" pattern with release
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See how multiplexing the inflammation signaling pathway with MILLIPLEX® inflammation assays or cell signaling assays can help researchers bridge the gap between immunology and cell signaling, including investigating T cell signaling, Th Cell differentiation, inflammatory response signaling, and sepsis signaling.
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