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Merck
CN

HKI2MAG-99K

MILLIPLEX® Human Kidney Injury Panel

Configurable Human Kidney Toxicity 7-plex Panel 2

别名:

Human Kidney Toxicity Multiplex Assay, Luminex® Human Kidney Toxicity Assay, Millipore Human Kidney Toxicity Panel

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关于此项目

UNSPSC Code:
12161503
NACRES:
NA.84
eCl@ss:
32161000

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产品名称

MILLIPLEX® Human Kidney Injury Panel, Configurable Human Kidney Toxicity 7-plex Panel 2

species reactivity

human

Quality Level

200

packaging

pkg of 1 ea

manufacturer/tradename

Milliplex®

assay range

accuracy: 95-109%, sensitivity: 0.015-5.359 ng/mL
(MinDC = 2SD), standard curve range: 0.01-10 ng/mL
(EGF), standard curve range: 0.02-20 ng/mL
(Lipocalin-2/ NGAL), standard curve range: 0.20-200 ng/mL
(Cystatin C), standard curve range: 0.59-600 ng/mL
(Osteopontin (OPN)), standard curve range: 0.98-1,000 ng/mL
(α-1-Microglobulin), standard curve range: 3.91-4,000 ng/mL
(Albumin), standard curve range: 4.88-5,000 ng/mL
(Clusterin), inter-assay cv: <20%
intra-assay cv: <10%

technique(s)

multiplexing: suitable

input

urine

detection method

fluorometric (Luminex® xMAP® technology)

shipped in

wet ice

storage temp.

2-8°C

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General description

Clusterin, Cystatin C, Lipocalin-2/NGAL, Osteopontin, and Uromodulin are key biomarkers associated with kidney injury, inflammation, and tubular function. These analytes provide insights into early renal damage, immune response, and epithelial integrity, making them valuable for studying acute kidney injury, chronic kidney disease, and nephrotoxicity. Their combined measurement supports comprehensive assessment of renal health and disease progression.

Application

MILLIPLEX® Qualified assays undergo rigorous assay development, verification, and Quality Control testing to achieve optimal performance. Simultaneously analyze up to 7 analytes in human urine samples.

Analytes included: α-1-Microglobulin, Albumin, Clusterin, Cystatin C, EGF, Lipocalin-2/NGAL, Osteopontin (OPN)

Assay Characteristics: Refer to kit protocol for assay cross-reactivity, sensitivity, precision, and accuracy.

Features and Benefits

Features:

  • 7-plex multiplexing allows simultaneous quantification of seven kidney injury biomarkers in human urine samples
  • Includes α-1-Microglobulin, Albumin, Clusterin, Cystatin C, EGF, Lipocalin-2/NGAL, and Osteopontin (OPN)
  • Magnetic bead-based format improves assay precision and simplifies washing steps
  • Utilizes Luminex® xMAP® technology for high-throughput analysis with minimal sample volume
  • Validated for use with human urine samples
  • Compatible with both manual and automated workflows
Benefits:

  • Enables early detection of renal injury before traditional markers show abnormalities
  • Provides comprehensive coverage of biomarkers involved in nephrotoxicity and renal dysfunction
  • Conserves valuable samples by measuring multiple analytes in a single assay
  • Accelerates research in drug development, toxicology, and translational studies
  • Delivers high sensitivity and specificity with minimal cross-reactivity

Legal Information

Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp

Disclaimer

For research use only. Not for use in diagnostic procedures.

Label License/Sticker for Assay Product:

By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1 - STOT RE 2

target_organs

Respiratory Tract

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

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Irene Capelli et al.
In vivo (Athens, Greece), 34(3), 1333-1339 (2020-05-02)
Acute kidney injury is an important cause of mortality in very-low-birth-weight (VLBW) preterm infants. As in the general population, the detection of renal damage cannot rely on the measurement of serum creatinine, since it has been demonstrated to be a

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