HMMP2MAG-55K
MILLIPLEX® 人MMP磁珠板2-免疫学多重检测
Configurable Human MMP 5-Plex Panel
别名:
Human matrix metalloproteinase multiplex kit, Luminex® Human MMP immunoassay, Millipore human MMP panel
产品名称
MILLIPLEX® 人MMP磁珠板2-免疫学多重检测,
species reactivity
human
Quality Level
description
Configurable Human MMP 5-Plex Panel
packaging
pkg of 1 ea
manufacturer/tradename
Milliplex®
assay range
accuracy: 72-98%, standard curve range: 14-10,000 pg/mL
(MMP-9), standard curve range: 27-20,000 pg/mL
(MMP-1), standard curve range: 27-20,000 pg/mL
(MMP-10), standard curve range: 548-400,000 pg/mL
(MMP-7), standard curve range: 68-50,000 pg/mL
(MMP-2)
technique(s)
multiplexing: suitable
input
cell culture supernatant
urine
serum
detection method
fluorometric (Luminex® xMAP® technology)
shipped in
wet ice
storage temp.
2-8°C
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General description
MMPs (matrix metalloproteinases), a family of zinc proteases responsible for the breakdown of extracellular matrix (ECM), play a key role in normal physiological processes, such as embryonic development and tissue morphogenesis, tissue and bone remodeling, wound healing, and angiogenesis. These processes rely on MMPs′ role in the cleavage of cell surface receptors, the release of apoptotic ligands, cell proliferation and differentiation, and chemokine activity modulation. Similar in structure, MMPs are synthesized and secreted as inactive pro-enzymes that require proteolytic cleavage for activation. This process can be mediated by serine proteases or other MMPs. An increase in MMP expression occurs in response to a wide range of stimuli, including adhesion molecules, growth factors, cytokines, and hormones. Regulation of MMP activity is controlled primarily by TIMPs (tissue inhibitors of metalloproteinases). Therefore, disruption of the MMP/TIMP balance can result in arthritis, cardiovascular disease and tumor growth and metastasis.
Application
MILLIPLEX® Qualified assays undergo rigorous assay development, verification, and Quality Control testing to achieve optimal performance. Simultaneously analyze up to 5 analytes in human serum, plasma, urine, and cell culture supernatants.
Analytes included: MMP-1, MMP-2, MMP-7, MMP-9, MMP-10
Assay Characteristics: Refer to kit protocol for assay cross-reactivity, sensitivity, precision, and accuracy.
Analytes included: MMP-1, MMP-2, MMP-7, MMP-9, MMP-10
Assay Characteristics: Refer to kit protocol for assay cross-reactivity, sensitivity, precision, and accuracy.
Features and Benefits
- Comprehensive MMP Coverage: Key MMPs involved in inflammation, cardiovascular disease, and cancer research for complete MMP/TIMP pathway analysis.
- Advanced Multiplex Technology: Luminex® xMAP® magnetic bead platform quantitates 5 critical MMPs (MMP-1, -2, -7, -9, -10) simultaneously in one well with superior speed and sensitivity in a single day.
- Flexible Design: Configure your panel by selecting specific analytes and scale from small studies to large trials, supporting diverse inflammation and immunology research applications.
- Sample Versatility: Compatible with human serum, plasma, urine, tissue/cell lysates, and culture supernatants using optimized dilutions that conserves sample volume for research applications.
- Research Applications: Target disease-relevant biomarkers in arthritis, cardiovascular disease, and cancer research to support biomarker discovery, mechanistic studies, and translational research programs.
- Research-Grade Quality: Verified for research use with standardized protocols, comprehensive technical support, and quality systems designed for multi-laboratory research collaborations.
Legal Information
Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp
Disclaimer
For research use only. Not for use in diagnostic procedures.
Label License/Sticker for Assay Product:
By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.
Label License/Sticker for Assay Product:
By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.
signalword
Danger
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1 - STOT RE 2
target_organs
Respiratory Tract
存储类别
10 - Combustible liquids
wgk
WGK 3
法规信息
新产品
此项目有
Mittal Jasoliya et al.
Brain sciences, 10(6) (2020-06-14)
Recent advances in neurobiology have provided several molecular entrees for targeted treatments for Fragile X syndrome (FXS). However, the efficacy of these treatments has been demonstrated mainly in animal models and has not been consistently predictive of targeted drugs' response
Yu Yue et al.
BioMed research international, 2020, 2961742-2961742 (2020-07-01)
The present study investigated the profiles of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) of the aqueous humor (AH) and plasma (PL) in myopia patients, to determine whether there was an association between these levels with their axial
Livia V Souza et al.
Nutrition, metabolism, and cardiovascular diseases : NMCD, 30(1), 60-70 (2019-11-23)
The purpose of this study was to investigate whether an intervention with physical activity (PA) would promote positive effects on the angiogenic factors, mobilization, and functionality of circulating endothelial progenitor cells (EPCs) in children with low birth weight (LBW). Thirty-five
Ulrike Müller et al.
Mediators of inflammation, 2015, 626530-626530 (2015-07-18)
In cystic fibrosis (CF) the upper (UAW) and lower airways (LAW) are reservoirs for pathogens like Pseudomonas aeruginosa. The consecutive hosts' release of proteolytic enzymes contributes to inflammation and progressive pulmonary destruction. Objectives were to assess dynamics of protease :
Dynamics of cerebrospinal fluid levels of matrix metalloproteinases in human traumatic brain injury.
Karolina Minta et al.
Scientific reports, 10(1), 18075-18075 (2020-10-24)
Matrix metalloproteinases (MMPs) are extracellular enzymes involved in the degradation of extracellular matrix (ECM) proteins. Increased expression of MMPs have been described in traumatic brain injury (TBI) and may contribute to additional tissue injury and blood-brain barrier damage. The objectives
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