产品名称
MILLIPLEX®人脓毒症磁珠板1-免疫应答多重测定,
species reactivity
human
Quality Level
description
Configurable Human Sepsis 6-Plex Panel 1
packaging
pkg of 1 ea
manufacturer/tradename
Milliplex®
assay range
accuracy: 111%
(sVCAM-1), accuracy: 114%
(MIF), accuracy: 98%
(sFas), standard curve range: 12-50,000 pg/mL
(sFas, sFasL, and PAI-1), standard curve range: 61-250,000 pg/mL
(sVCAM-1 and sICAM-1)
technique(s)
multiplexing: suitable
input
serum
cell culture supernatant
detection method
fluorometric (Luminex® xMAP® technology)
shipped in
wet ice
storage temp.
2-8°C
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General description
Sepsis or SIRS (systemic inflammatory response syndrome) results from infection, whether bacterial, viral, fungal, or parasitic. The pathogenesis of sepsis is very complex. Both an innate and acquired immune response to infection interrupts homeostasis with a shift of cytokine expression that increases immunosuppression. In addition, migration of the leukocytes in the inflamed tissues secretes a tissue factor leading to the formation of thrombin, also triggering the release of chemokines and adhesion molecules through endothelial cells. Severe sepsis occurs when hypotension or hypoperfusion to one or more organs leads to organ dysfunction, which, in turn, can cause septic shock, multiple organ dysfunction syndrome (MODS) and death.
Application
MILLIPLEX® Qualified assays undergo rigorous assay development, verification, and Quality Control testing to achieve optimal performance. Simultaneously analyze up to 6 analytes in human serum, plasma, and cell culture supernatants.
Analytes included: MIF, PAI-1 (Total), sFas, sFasL, sICAM-1, sVCAM-1
Assay Characteristics: Refer to kit protocol for assay cross-reactivity, sensitivity, precision, and accuracy.
Analytes included: MIF, PAI-1 (Total), sFas, sFasL, sICAM-1, sVCAM-1
Assay Characteristics: Refer to kit protocol for assay cross-reactivity, sensitivity, precision, and accuracy.
Features and Benefits
- Vascular and Apoptotic Research Panel: Luminex® xMAP® platform simultaneously quantitates 6 critical sepsis biomarkers (sFAS/TNFRSF6, sFasL, sICAM-1, MIF, PAI-1 total, sVCAM-1) targeting vascular dysfunction and apoptotic pathways in sepsis research.
- Versatile Sample Compatibility: Designed for human serum, plasma, tissue culture supernatants, and homogenates using 1:10 dilution for serum/plasma samples, accommodating diverse sepsis research applications and sample types.
- Endothelial Dysfunction Research: Investigate vascular adhesion molecules (sICAM-1, sVCAM-1), coagulation dysregulation (PAI-1), inflammatory mediators (MIF), and apoptotic signaling (sFas, sFasL) critical to sepsis-induced organ dysfunction.
- Specialized Research Applications: Target biomarkers specifically involved in endothelial activation, thrombotic complications, and programmed cell death pathways that characterize severe sepsis and progression to MODS in research studies.
Legal Information
Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp
Disclaimer
For research use only. Not for use in diagnostic procedures.
Label License/Sticker for Assay Product:
By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.
Label License/Sticker for Assay Product:
By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.
signalword
Warning
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
target_organs
Respiratory system
存储类别
10 - Combustible liquids
wgk
WGK 3
法规信息
新产品
此项目有
Sigita Kazune et al.
Critical care (London, England), 23(1), 311-311 (2019-09-13)
In patients with septic shock, the skin is often chosen for the evaluation of peripheral perfusion and oxygenation. Changes in skin microcirculatory vessel oxygen saturation and relative hemoglobin concentration can be described using a mottling score or captured with hyperspectral
Dai Kimura et al.
Frontiers in pediatrics, 4, 31-31 (2016-04-12)
Lung injury activates multiple pro-inflammatory pathways, including neutrophils, epithelial, and endothelial injury, and coagulation factors leading to acute respiratory distress syndrome (ARDS). Low-dose methylprednisolone therapy (MPT) improved oxygenation and ventilation in early pediatric ARDS without altering duration of mechanical ventilation
Sonia Y Velásquez et al.
The Journal of biological chemistry, 291(25), 12960-12977 (2016-04-30)
Natural killer (NK) cells induce apoptosis in infected and transformed cells and are important producers of immunoregulatory cytokines. Therefore, they operate under low oxygen conditions (hypoxia) in inflammatory and tumor environments. In vitro studies of NK cells are, however, commonly
Miša Korva et al.
Viruses, 11(8) (2019-07-31)
Hemorrhagic fever with renal syndrome (HFRS) and Crimean-Congo hemorrhagic fever (CCHF) are important viral hemorrhagic fevers (VHF), especially in the Balkan region. Infections with Dobrava or Puumala orthohantavirus and Crimean-Congo hemorrhagic fever orthonairovirus can vary from a mild, nonspecific febrile
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Immunology multiplex assays, like MILLIPLEX® assays, allow researchers to investigate more immune biomarkers simultaneously, saving time and resources.
See how multiplexing the inflammation signaling pathway with MILLIPLEX® inflammation assays or cell signaling assays can help researchers bridge the gap between immunology and cell signaling, including investigating T cell signaling, Th Cell differentiation, inflammatory response signaling, and sepsis signaling.
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