MAB11004
抗-hnRNP Q 抗体（克隆7A11.2）
clone 7A11.2, from mouse
别名:
heterogeneous nuclear ribonucleoprotein Q-like, Synaptotagmin-binding, cytoplasmic RNA-interacting protein, Glycine- and tyrosine-rich RNA-binding protein, GRY-RBP, NS1-associated protein 1
产品名称
抗-hnRNP Q 抗体（克隆7A11.2）, clone 7A11.2, from mouse
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
7A11.2, monoclonal
species reactivity
mouse, rat, human
technique(s)
immunocytochemistry: suitable
western blot: suitable
isotype
IgG1κ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... SYNCRIP(10492)
Analysis Note
通过蛋白质印迹在NIH/3T3细胞裂解液中进行了评估。
蛋白质印迹分析：1 µg/mL的该抗体可在10 µg NIH/3T3细胞裂解液中检测到hnRNP Q。
蛋白质印迹分析：1 µg/mL的该抗体可在10 µg NIH/3T3细胞裂解液中检测到hnRNP Q。
Application
抗-hnRNP Q抗体（克隆7A11.2）是一种小鼠单克隆抗体，用于检测hnRNP Q，也称为异质核核糖核蛋白Q，&已在WB、ICC中进行了验证。
蛋白质印迹分析：1 µg/mL的代表性批次在10 µg PC-12和HEK293细胞裂解物中检测到hnRNP Q 。
免疫细胞化学分析： 一个代表性批次的1：500稀释液在 NIH/3T3、A431和HeLa细胞中检测到hnRNP Q。
免疫细胞化学分析： 一个代表性批次的1：500稀释液在 NIH/3T3、A431和HeLa细胞中检测到hnRNP Q。
General description
异质核核糖核蛋白Q，常被称为hnRNP Q，由于单个基因的可变剪接存在三种不同亚型。该RNA结合蛋白与运动神经元（SMN）蛋白存活所需的mRNA 前体剪接的控制有关。SMN的功能丧失性突变与一种常见的神经退行性疾病，脊髓性肌肉萎缩症（SMA）有关。研究显示hnRNP Q 蛋白与SMN相互作用，这种相互作用是高效的体外pre-mRNA剪接所必需的。当前数据表明hnRNP Q 是SMN的剪接调节因子。
观测值〜59。在某些裂解物中可能观察到未多种亚型。
Immunogen
对应于人hnRNPQ的全长重组蛋白。
Other Notes
浓度：请参考批次特异性浓缩物的检验报告。
Physical form
形式：纯化
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Florisela Herrejon Chavez et al.
Nature communications, 14(1), 2290-2290 (2023-04-22)
Tissue homeostasis is maintained after stress by engaging and activating the hematopoietic stem and progenitor compartments in the blood. Hematopoietic stem cells (HSCs) are essential for long-term repopulation after secondary transplantation. Here, using a conditional knockout mouse model, we revealed
Veronica Riccioni et al.
International journal of molecular sciences, 23(2) (2022-01-22)
Heterogeneous nuclear ribonucleoproteins (hnRNPs) control gene expression by acting at multiple levels and are often deregulated in epithelial tumors; however, their roles in the fine regulation of cellular reprogramming, specifically in epithelial-mesenchymal transition (EMT), remain largely unknown. Here, we focused
Ly P Vu et al.
Nature genetics, 49(6), 866-875 (2017-04-25)
The identity of the RNA-binding proteins (RBPs) that govern cancer stem cells remains poorly characterized. The MSI2 RBP is a central regulator of translation of cancer stem cell programs. Through proteomic analysis of the MSI2-interacting RBP network and functional shRNA
Charles R Dixon et al.
iScience, 24(9), 103055-103055 (2021-09-21)
STimulator of INterferon Genes (STING) is an adaptor for cytoplasmic DNA sensing by cGAMP/cGAS that helps trigger innate immune responses (IIRs). Although STING is mostly localized in the ER, we find a separate inner nuclear membrane pool of STING that
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