MAB1563
抗早老素1抗体（NT，克隆hPS1-NT）
culture supernatant, clone hPS1-NT, Chemicon®
别名:
Anti-ACNINV3, Anti-FAD, Anti-PS-1, Anti-PS1, Anti-S182
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
hPS1-NT, monoclonal
Application:
ELISA
immunohistochemistry
immunoprecipitation (IP)
western blot
immunohistochemistry
immunoprecipitation (IP)
western blot
Species reactivity:
human
Citations:
57
Technique(s):
ELISA: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
Uniprot accession no.:
产品名称
抗早老素1抗体（NT，克隆hPS1-NT）, culture supernatant, clone hPS1-NT, Chemicon®
biological source
rat
conjugate
unconjugated
antibody form
culture supernatant
antibody product type
primary antibodies
clone
hPS1-NT, monoclonal
species reactivity
human
manufacturer/tradename
Chemicon®
technique(s)
ELISA: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
isotype
IgG2a
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... PSEN1(5663)
Analysis Note
对照
脑组织
脑组织
Application
免疫组化：大鼠幼仔和24月龄大鼠以100-200mL 含有4% PFA、0.3%戊二醛和0.1%CaCl2的0.1M PBS（pH 7.4）灌注10分钟。 振动切片机切片用3%正常血清封闭，然后以 0.1% triton X-100.透化（Neuroscience 2003 120:405-423}.
免疫印迹：1：250-1：500。建议的封闭缓冲液是含有5%无脂牛奶和0.01%吐温20的TBS。建议您也在该封闭液中稀释抗体。 与MAB1563一起室温培养1至 2 小时或4°C 过夜。
免疫沉淀
ELISA
最佳工作稀释度必须由最终用户确定。
免疫印迹：1：250-1：500。建议的封闭缓冲液是含有5%无脂牛奶和0.01%吐温20的TBS。建议您也在该封闭液中稀释抗体。 与MAB1563一起室温培养1至 2 小时或4°C 过夜。
免疫沉淀
ELISA
最佳工作稀释度必须由最终用户确定。
研究子类别
神经退行性疾病
神经退行性疾病
研究类别
神经科学
神经科学
该抗早老素1抗体经过验证可用在ELISA、IH、IP、WB中检测早老素1。
Biochem/physiol Actions
识别人早老素1。通过蛋白质印迹，该抗体可识别各种样品中（包括转染人PS1互补DNA的PC12细胞、痴呆患者脑解剖标本，以及家族性阿尔茨海默病患者、晚发型阿尔茨海默病患者和其他退行性疾病患者的额叶新层的尸检样品）一种32 kDa的主要多肽。对照大脑的免疫组化研究表明PS1主要在神经元中表达，蛋白质位于身体和树状突。与FAD和零星的阿尔茨海默病患者形成对比的是，PS1的免疫反应性出现在老年斑的神经炎部分以及神经原纤维缠结中。家族性和零星的阿尔茨海默病的PS1免疫反应性定位表明该疾病的遗传异质形式（genetically heterogeneous form）具有共同的涉及PS1蛋白的病理学。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
32kda
Immunogen
融合蛋白抗原，含有与GST融合的人PS-1 （残基21-80） 的N末端。
表位：N端
Other Notes
浓度：请参考批次特异性浓缩物的检验报告。
Physical form
未纯化
来自灌注系统的未纯化小鼠组织培养物上清液，在装入小瓶之前通过0.2μ微米膜过滤。产品包含20%FBS和环丙沙星，终浓度为10μg/mL。
Preparation Note
自收到之日起在-20°C可稳定保存1年。避免反复冻融。为了最大程度地回收产品，在融化后和取下盖子之前，将原始小瓶进行离心。
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Sun Young Oh et al.
Journal of neurochemistry, 113(1), 262-274 (2010-01-22)
The amyloid precursor protein is a ubiquitously expressed transmembrane protein that has been long implicated in the pathogenesis of Alzheimer's disease but its normal biological function has remained elusive despite extensive effort. We have previously reported the identification of Notch2
Lindsay Poppe et al.
Alzheimer's research & therapy, 11(1), 102-102 (2019-12-14)
EphA4 is a receptor of the ephrin system regulating spine morphology and plasticity in the brain. These processes are pivotal in the pathophysiology of Alzheimer's disease (AD), characterized by synapse dysfunction and loss, and the progressive loss of memory and
Marty A Fernandez et al.
The Journal of biological chemistry, 289(45), 31043-31052 (2014-09-23)
The presenilin-containing γ-secretase complex produces the amyloid β-peptide (Aβ) through intramembrane proteolysis, and >100 presenilin mutations are associated with familial early-onset Alzheimer disease (AD). The question of whether these mutations result in AD through a gain or a loss of
Sophie Ayciriex et al.
The Biochemical journal, 473(3), 321-334 (2016-01-27)
γ-Secretase is a multi-subunit membrane protease complex that catalyses the final intramembrane cleavage of the β-amyloid precursor protein (APP) during the neuronal production of amyloid-β peptides (Aβ), which are implicated as the causative agents of Alzheimer's disease (AD). In the present
Jyoti Chhibber-Goel et al.
The Journal of biological chemistry, 291(11), 5971-5985 (2016-01-13)
The γ-secretase protease and associated regulated intramembrane proteolysis play an important role in controlling receptor-mediated intracellular signaling events, which have a central role in Alzheimer disease, cancer progression, and immune surveillance. An increasing number of γ-secretase substrates have a role
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