产品名称
肌营养不良蛋白抗体，克隆1808, clone 1808, Chemicon®, from mouse
biological source
mouse
antibody form
purified antibody
antibody product type
primary antibodies
clone
1808, monoclonal
species reactivity
chicken, mouse, rat, human
manufacturer/tradename
Chemicon®
technique(s)
immunohistochemistry: suitable
western blot: suitable
isotype
IgG1
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... DMD(1756)
Application
肌营养不良蛋白抗体（克隆1808）可检测肌营养不良蛋白水平 & 已发表 & 经验证可用于 WB、IH。
蛋白质印迹
免疫组化
最佳工作稀释度必须由最终用户确定。
免疫组化
最佳工作稀释度必须由最终用户确定。
Biochem/physiol Actions
通过蛋白质印迹，MAB1645可识别相对分子量为300 kD的单一蛋白。可与哺乳动物骨骼肌肌营养不良蛋白反应。无法对mdx小鼠肌肉进行染色。可标记正常人体肌肉，但无法标记杜氏肌肉。
染色模式：
在正常小鼠膈肌冷冻切片上，MAB1645可对整个肌膜进行强免疫荧光染色，对神经肌肉接头的染色尤为强烈。
种属反应性：
可标记大鼠、鸡和非洲爪蟾的骨骼肌。可标记大鼠和正常（但不是mdx）小鼠的心肌。还可标记鸡胗平滑肌。
染色模式：
在正常小鼠膈肌冷冻切片上，MAB1645可对整个肌膜进行强免疫荧光染色，对神经肌肉接头的染色尤为强烈。
种属反应性：
可标记大鼠、鸡和非洲爪蟾的骨骼肌。可标记大鼠和正常（但不是mdx）小鼠的心肌。还可标记鸡胗平滑肌。
Immunogen
从电鳐属突触后膜提取的外周膜蛋白。
Physical form
形式：纯化
液体，溶于含有0.25 mM NaCl和0.1%叠氮化钠的0.02M磷酸盐缓冲液（pH 7.6）中。
Preparation Note
以方便的等分试样在-20ºC保持长达12个月。应避免反复冻/融循环。
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Andreas Schaefer et al.
PloS one, 11(2), e0148259-e0148259 (2016-02-04)
Previous small animal models for simulation of mechanical unloading are solely performed in healthy or infarcted hearts, not representing the pathophysiology of hypertrophic and dilated hearts emerging in heart failure patients. In this article, we present a new and economic
Andreas Schaefer et al.
Scientific reports, 9(1), 5710-5710 (2019-04-07)
Mechanical unloading (MU) by implantation of left ventricular assist devices (LVAD) has become clinical routine. This procedure has been shown to reverse cardiac pathological remodeling, with the underlying molecular mechanisms incompletely understood. Most studies thus far were performed in non-standardized
Payam Soltanzadeh et al.
Neuromuscular disorders : NMD, 20(8), 499-504 (2010-07-16)
Manifesting carriers of DMD gene mutations may present diagnostic challenges, particularly in the absence of a family history of dystrophinopathy. We review the clinical and genetic features in 15 manifesting carriers identified among 860 subjects within the United Dystrophinopathy Project
Mariana Fernandez-Caggiano et al.
Nature metabolism, 2(11), 1223-1231 (2020-10-28)
Cardiomyocytes rely on metabolic substrates, not only to fuel cardiac output, but also for growth and remodelling during stress. Here we show that mitochondrial pyruvate carrier (MPC) abundance mediates pathological cardiac hypertrophy. MPC abundance was reduced in failing hypertrophic human
Tessa R Werner et al.
Scientific reports, 9(1), 11494-11494 (2019-08-09)
Afterload enhancement (AE) of rat engineered heart tissue (EHT) in vitro leads to a multitude of changes that in vivo are referred to as pathological cardiac hypertrophy: e.g., cardiomyocyte hypertrophy, contractile dysfunction, reactivation of fetal genes and fibrotic changes. Moreover
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