biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
P1H4, monoclonal
species reactivity
human, primate
manufacturer/tradename
Chemicon®
technique(s)
ELISA: suitable, flow cytometry: suitable, immunocytochemistry: suitable, immunohistochemistry: suitable, immunoprecipitation (IP): suitable
isotype
IgG1
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... ITGA4(3676)
Application
免疫组化（优选固定剂为丙酮和醇类）
免疫细胞化学
免疫沉淀
FACS 分析
ELISA
放射性免疫测定
生物活性MAB16983 抑制CS-1 和VCAM结合。
最佳工作稀释度必须由最终用户进行确定。
免疫细胞化学
免疫沉淀
FACS 分析
ELISA
放射性免疫测定
生物活性MAB16983 抑制CS-1 和VCAM结合。
最佳工作稀释度必须由最终用户进行确定。
抗整合素α4抗体（克隆P1H4）可检测整合素α4 &水平&已有相关文献发表&经验证可用于ELISA、FC、IC、IH IP。
Biochem/physiol Actions
整合素在血管增殖、粘附和伤口修复中的作用已被充分证明。细胞粘附受体的整合素家族由至少16种膜相关的异二聚体组成，由以非共价方式缔合的α和β亚基组成。整合素家族的结构和功能多样性基于各个α和β亚基的配对能力。单克隆抗体 MAB16983由人T淋巴细胞通过免疫生产。 该抗体可与灵长类动物和人的整合素a4 发生反应。
Physical form
形式：纯化
通过蛋白 A琼脂糖™色谱纯化的免疫球蛋白。 溶于0.02M PBS （pH 7.6）、0.25M NaCl，含有 0.01% 叠氮化钠的液体。
Preparation Note
在+2-8C下保存。
Other Notes
替代：04-1131
浓度：请参考批次特异性浓缩物的检验报告。
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Sepharose is a trademark of Cytiva
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wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
存储类别
12 - Non Combustible Liquids
Rhiannon M Kelsh-Lasher et al.
The Journal of investigative dermatology, 137(12), 2505-2512 (2017-08-27)
Alternative splicing of fibronectin increases expression of the EDA+ isoform of fibronectin (EDA+Fn), a damage-associated molecular pattern molecule, which promotes fibro-inflammatory disease through the activation of toll-like receptors. Our studies indicate that the fibronectin EDA domain drives two waves of
Rika Tanaka et al.
The Journal of biological chemistry, 284(30), 19817-19825 (2009-05-23)
Fibronectin plays important roles in erythropoiesis through the fibronectin receptors VLA-4 and VLA-5. However, the substantial role of these fibronectin receptors and their functional assignment in erythroid differentiation are not yet fully understood. Here, we investigated the effects of cell
Marco R Schroeter et al.
Circulation research, 103(5), 536-544 (2008-07-29)
The adipocytokine leptin modulates vascular remodeling and neointima formation. Because endothelial progenitor cells (EPCs) participate in vascular repair, we analyzed the effects of leptin on human EPC function in vitro and in vivo. After 7 days in culture, EPCs expressed
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| MAB16983 | 04053252465963 |