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Merck
CN

MAB16983

抗整合素α4抗体(克隆P1H4)

clone P1H4, Chemicon®, from mouse

别名:

CD49d

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关于此项目

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
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产品名称

抗整合素α4抗体(克隆P1H4), clone P1H4, Chemicon®, from mouse

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

P1H4, monoclonal

species reactivity

human, primate

manufacturer/tradename

Chemicon®

technique(s)

ELISA: suitable
flow cytometry: suitable
immunocytochemistry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable

isotype

IgG1

NCBI accession no.

UniProt accession no.

shipped in

wet ice

target post-translational modification

unmodified

Quality Level

Gene Information

human ... ITGA4(3676)

Application

免疫组化(优选固定剂为丙酮和醇类)

免疫细胞化学

免疫沉淀

FACS 分析

ELISA

放射性免疫测定

生物活性MAB16983 抑制CS-1 和VCAM结合。

最佳工作稀释度必须由最终用户进行确定。
抗整合素α4抗体(克隆P1H4)可检测整合素α4 &水平&已有相关文献发表&经验证可用于ELISA、FC、IC、IH IP。

Biochem/physiol Actions

整合素在血管增殖、粘附和伤口修复中的作用已被充分证明。细胞粘附受体的整合素家族由至少16种膜相关的异二聚体组成,由以非共价方式缔合的α和β亚基组成。整合素家族的结构和功能多样性基于各个α和β亚基的配对能力。单克隆抗体 MAB16983由人T淋巴细胞通过免疫生产。 该抗体可与灵长类动物和人的整合素a4 发生反应。

Other Notes

替代:04-1131
浓度:请参考批次特异性浓缩物的检验报告。

Physical form

形式:纯化
通过蛋白 A琼脂糖色谱纯化的免疫球蛋白。 溶于0.02M PBS (pH 7.6)、0.25M NaCl,含有 0.01% 叠氮化钠的液体。

Preparation Note

在+2-8C下保存。

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Sepharose is a trademark of Cytiva

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存储类别

10 - Combustible liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


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Marco R Schroeter et al.
Circulation research, 103(5), 536-544 (2008-07-29)
The adipocytokine leptin modulates vascular remodeling and neointima formation. Because endothelial progenitor cells (EPCs) participate in vascular repair, we analyzed the effects of leptin on human EPC function in vitro and in vivo. After 7 days in culture, EPCs expressed
Rhiannon M Kelsh-Lasher et al.
The Journal of investigative dermatology, 137(12), 2505-2512 (2017-08-27)
Alternative splicing of fibronectin increases expression of the EDA+ isoform of fibronectin (EDA+Fn), a damage-associated molecular pattern molecule, which promotes fibro-inflammatory disease through the activation of toll-like receptors. Our studies indicate that the fibronectin EDA domain drives two waves of
Rika Tanaka et al.
The Journal of biological chemistry, 284(30), 19817-19825 (2009-05-23)
Fibronectin plays important roles in erythropoiesis through the fibronectin receptors VLA-4 and VLA-5. However, the substantial role of these fibronectin receptors and their functional assignment in erythroid differentiation are not yet fully understood. Here, we investigated the effects of cell
Integrin alpha9beta1 mediates enhanced cell migration through nitric oxide synthase activity regulated by Src tyrosine kinase.
Gupta, SK; Vlahakis, NE
Journal of Cell Science null
Yohei Saito et al.
The Journal of biological chemistry, 285(10), 7006-7015 (2009-12-17)
It has been postulated that inactivated beta1-integrins are involved in the disordered growth of hematopoietic tumor cells. We recently found that TNIIIA2, a peptide derived from tenascin-C, strongly activates beta1-integrins through binding with syndecan-4. We show here that Ramos Burkitt's

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