产品名称
Anti-Scribble Antibody, clone 7C6.D10, Chemicon®, from mouse
biological source
mouse
conjugate
unconjugated
antibody form
purified antibody
antibody product type
primary antibodies
clone
7C6.D10, monoclonal
species reactivity
human
manufacturer/tradename
Chemicon®
technique(s)
western blot: suitable
isotype
IgG1κ
GenBank accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... SCRIB(23513)
Analysis Note
Routinely evaluated by Western blot on HeLa cell lysates.
Application
Suggested dilutions:
Western blot: 0.2 µg (1:2000)
Western blot: 0.2 µg (1:2000)
Research Sub Category
Tumor Markers
Cytoskeleton
Tumor Markers
Cytoskeleton
This Anti-Scribble Antibody is validated for use in WB for the detection of Scribble.
Biochem/physiol Actions
Predicted to cross react with mouse based on sequence homology. Reactivity with other species has not been tested.
General description
220 kDa
Scribble is a tumor suppressor marker first discovered in Drosophila that has been implicated in the control of cell proliferation, polarity, invasion, and metastasis (Humbert, et al, 2003). Mammalian Scribble expresses basolateral staining in epithelial tissue and highly polarized expression in T lymphocytes (Dow, et al, 2003) (Ludford-Menting, et al, 2005), and plays an essential role in the regulation of the polarity specifically involved in directed epithelial migration. Altered expression of human Scribble is associated with invasive epithelial cancers, however, its role in tumour development remains unclear (Dow, et al, 2007).
Immunogen
Epitope: PDZ2 domain of Scribble
GST-tagged fusion protein corresponding to the PDZ2 domain of Scribble
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Physical form
Format: Purified
Purified in PBS containing with 0.05% NaN3.
Preparation Note
Maintain at 2-8°C for up to 1 year after date of receipt.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
GenBank is a registered trademark of United States Department of Health and Human Services
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存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Sang Joon Won et al.
ACS chemical biology, 13(6), 1560-1568 (2018-05-08)
S-palmitoylation is required for membrane anchoring, proper trafficking, and the normal function of hundreds of integral and peripheral membrane proteins. Previous bioorthogonal pulse-chase proteomics analyses identified Ras family GTPases, polarity proteins, and G proteins as rapidly cycling S-palmitoylated proteins sensitive
I F Bambang et al.
Oncogene, 32(10), 1240-1251 (2012-05-01)
The epithelial-mesenchymal transition (EMT) correlates with disruption of cell-cell adhesion, loss of cell polarity and development of epithelial cell malignancy. Identifying novel molecules that inhibit EMT has profound potential for developing mechanism-based therapeutics. We previously demonstrated that the endoplasmic reticulum
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