MAB1973Z
Anti-Integrin α1 Antibody, clone FB12, azide free
clone FB12, Chemicon®, from mouse
别名:
CD49a, MAB1973
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
FB12, monoclonal
Application:
ELISA, FACS, IHC, IP, WB
Citations:
22
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
FB12, monoclonal
species reactivity
human
manufacturer/tradename
Chemicon®
technique(s)
ELISA: suitable, flow cytometry: suitable, immunohistochemistry: suitable, immunoprecipitation (IP): suitable, western blot: suitable
isotype
IgG1
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... ITGA1(3672)
General description
130 kDa
Application
Detect Integrin α1 using this Anti-Integrin α1 Antibody, clone FB12, azide free validated for use in ELISA, FC, IH, IP, FUNC & WB.
Immunohistochemistry: 2 μg/mL, with paraformaldehyde fixation. Immunoblotting: 2 μg/mL
Immunoprecipitation: 1 μg/mL
FACS analysis: 2 μg/mL
ELISA: 0.5 μg/mL
Inhibition of activated human lymphocyte binding to laminin, collagen IV and fibronectin (Fabbri, 1996): 1-5 μg/mL
Optimal working dilutions must be determined by end user.
Immunoprecipitation: 1 μg/mL
FACS analysis: 2 μg/mL
ELISA: 0.5 μg/mL
Inhibition of activated human lymphocyte binding to laminin, collagen IV and fibronectin (Fabbri, 1996): 1-5 μg/mL
Optimal working dilutions must be determined by end user.
Biochem/physiol Actions
Reacts with the I domain (Val151 - Ala364) of human alpha1 integrin (Fabbri, 1996). Precipitates proteins of Mr 180 kDa, pI 5.9-6.0 (alpha chain) and Mr 115 kDa, pI 4.5-5.0 (beta chain) from human lymphocyte lysates (Zocchi, 1991). Does not recognize recombinant I domain of rat integrin alpha1.
Physical form
Format: Purified
Purified immunoglobulin in 0.02M PB, pH 7.6, 0.25M NaCl.
Analysis Note
Control
Microvascular endothelium
Microvascular endothelium
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Yasuhiro Katayama et al.
International journal of molecular sciences, 21(6) (2020-03-19)
Keloids are dermal fibroproliferative tumors that arise beyond the boundary of the original wound edges and invades adjacent tissue. Keloids are characterized by the extensive production of extracellular matrix (ECM) and abnormal fibroblast proliferation. Chondroitin sulfate (CS) is one of
Shawn M Sweeney et al.
The Journal of biological chemistry, 278(33), 30516-30524 (2003-06-06)
Angiogenesis depends on proper collagen biosynthesis and cross-linking, and type I collagen is an ideal angiogenic scaffold, although its mechanism is unknown. We examined angiogenesis using an assay wherein confluent monolayers of human umbilical vein endothelial cells were overlain with
Tobias Gerber et al.
Oncotarget, 8(1), 846-862 (2016-12-03)
Recent technological advances in single-cell genomics make it possible to analyze cellular heterogeneity of tumor samples. Here, we applied single-cell RNA-seq to measure the transcriptomes of 307 single cells cultured from three biopsies of three different patients with a BRAF/NRAS
Integrin upregulation and localization to focal adhesion sites in pregnant human myometrium.
Burkin, HR; Rice, M; Sarathy, A; Thompson, S; Singer, CA; Buxton, IL
Reproductive Sciences null
Christopher L Gilchrist et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 25(6), 829-840 (2007-02-24)
Cellular interactions with the extracellular matrix are key factors regulating cell survival, differentiation, and response to environmental stimuli in cartilagenous tissues. Much is known about the extracellular matrix proteins in the intervertebral disc (IVD) and their variations with region, age
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