产品名称
Anti-Integrin β1 Antibody, clone HB1.1, clone HB1.1, Chemicon®, from mouse
biological source
mouse
Quality Level
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
HB1.1, monoclonal
species reactivity
human, pig
manufacturer/tradename
Chemicon®
technique(s)
flow cytometry: suitable, immunohistochemistry: suitable, immunoprecipitation (IP): suitable, western blot: suitable
isotype
IgG1κ
suitability
not suitable for activity/function inhibition
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... ITGB1(3688)
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Application
Immunoprecipitation of VLA integrins from lysate of 10E6 cell equivalent requires 2 μg of MAB2000.
Flow cytometry: 10 μg/mL
Western blot
Immunohistochemistry in frozen tissue samples: 5 μg/mL
Induction of cell aggregation: 10 μg/mL. MAB2000 is a potent stimulator of cell aggregation tested in U937, Jurkat and human peripheral blood lymphocytes.
MAB2000 does not affect VLA integrin-mediated cell adhesion to matrix proteins.
Optimal working dilutions must be determined by end user.
Flow cytometry: 10 μg/mL
Western blot
Immunohistochemistry in frozen tissue samples: 5 μg/mL
Induction of cell aggregation: 10 μg/mL. MAB2000 is a potent stimulator of cell aggregation tested in U937, Jurkat and human peripheral blood lymphocytes.
MAB2000 does not affect VLA integrin-mediated cell adhesion to matrix proteins.
Optimal working dilutions must be determined by end user.
Research Category
Cell Structure
Cell Structure
Anti-Integrin β1 Antibody, clone HB1.1 detects level of Integrin β1 & has been published & validated for use in FC, IP, WB, IH.
Research Sub Category
Integrins
Integrins
Biochem/physiol Actions
Reacts with beta-1 subunit of VLA integrins
Physical form
Format: Purified
Purified immunoglobulin from Protein A chromatography. Liquid in 0.02M PB pH 7.6, 0.25M NaCl with 0.1% sodium azide.
Preparation Note
Maintain at 2-8°C for up to 6 months after date of receipt.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Replaces: 04-1109
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
存储类别
12 - Non Combustible Liquids
Roland Thuenauer et al.
mBio, 11(2) (2020-03-12)
The opportunistic bacterium Pseudomonas aeruginosa produces the fucose-specific lectin LecB, which has been identified as a virulence factor. LecB has a tetrameric structure with four opposing binding sites and has been shown to act as a cross-linker. Here, we demonstrate
Phosphoinositide signaling regulates the exocyst complex and polarized integrin trafficking in directionally migrating cells.
Thapa, N; Sun, Y; Schramp, M; Choi, S; Ling, K; Anderson, RA
Developmental Cell null
Agnes Arthur et al.
Stem cells (Dayton, Ohio), 26(7), 1787-1795 (2008-05-24)
Human adult dental pulp stem cells (DPSCs) reside within the perivascular niche of dental pulp and are thought to originate from migrating cranial neural crest (CNC) cells. During embryonic development, CNC cells differentiate into a wide variety of cell types
Amy M Lum et al.
BMC cancer, 10, 40-40 (2010-02-13)
GPR110 is an orphan G protein-coupled receptor--a receptor without a known ligand, a known signaling pathway, or a known function. Despite the lack of information, one can assume that orphan receptors have important biological roles. In a retroviral insertion mutagenesis
Wulin Aerbajinai et al.
The Journal of biological chemistry, 291(16), 8549-8564 (2016-02-21)
Monocyte migration requires the dynamic redistribution of integrins through a regulated endo-exocytosis cycle, but the complex molecular mechanisms underlying this process have not been fully elucidated. Glia maturation factor-γ (GMFG), a novel regulator of the Arp2/3 complex, has been shown
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| MAB2000 | 04053252464430 |
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