生物来源
mouse
质量水平
抗体形式
affinity purified immunoglobulin
抗体产品类型
primary antibodies
克隆
14.2Ga, monoclonal
种属反应性
human
制造商/商品名称
Chemicon®
技术
flow cytometry: suitable
immunofluorescence: suitable
immunohistochemistry: suitable
同位素/亚型
IgG2a
运输
wet ice
靶向翻译后修饰
unmodified
应用
免疫组织化学（冷冻组织切片）（Cheresh et al.，1986）
培养细胞的免疫荧光
流式细胞术：每10E6个细胞1-2 μg
对GD2阳性细胞的细胞毒性（Mujoo et al., 1987, 1989）
最佳工作稀释度必须由最终用户确定。
培养细胞的免疫荧光
流式细胞术：每10E6个细胞1-2 μg
对GD2阳性细胞的细胞毒性（Mujoo et al., 1987, 1989）
最佳工作稀释度必须由最终用户确定。
抗双唾液酸神经节苷脂抗体，clone 14G2a 检测双唾液酸神经节苷脂 GD2 &的水平，已发表验证可用于 FC、IF、IH。
生化/生理作用
与人 GD2 神经节苷脂特异性反应。
外形
形式：纯化
溶于0.02 M PB pH值7.6、0.25 M NaCl、含有0.1%叠氮化钠的细胞培养上清液。
其他说明
浓度：请参考批次特异性浓缩物的检验报告。
法律信息
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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储存分类代码
10 - Combustible liquids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Patrizia Garbati et al.
International journal of molecular sciences, 22(13) (2021-07-03)
High-risk neuroblastoma (HR-NB) still remains the most dangerous tumor in early childhood. For this reason, the identification of new therapeutic approaches is of fundamental importance. Recently, we combined the conventional pharmacological approach to NB, represented by cisplatin, with fendiline hydrochloride
Christian M Seitz et al.
Oncoimmunology, 9(1), 1683345-1683345 (2020-02-01)
Expression of the disialoganglioside GD2 has been identified as a marker antigen associated with a breast cancer stem-like cell (BCSC) phenotype. Here, we report on the evaluation of GD2 as a BCSC-specific target antigen for immunotherapy. GD2 expression was confirmed
Antonella Brizzolara et al.
Molecules (Basel, Switzerland), 25(22) (2020-11-14)
Despite significant improvement of neuroblastoma (NB) patients' survival due to recent treatment advancements in recent years, NB is still associated with high mortality rate. In search of novel strategies to increase NB's susceptibility to pharmacological treatments, we investigated the in
Martin V Kolev et al.
Journal of immunology (Baltimore, Md. : 1950), 184(11), 6035-6042 (2010-04-28)
Tumor cells escape clearance by complement by abundantly expressing CD59 and other membrane complement regulators. Recently, we designed a peptide derived from the neural-restrictive silencer factor (REST), REST68, which we showed to inhibit expression of CD59 in tumors lacking the
Hideki Yoshida et al.
Scientific reports, 10(1), 1199-1199 (2020-01-29)
β-1,4-N-Acetyl-Galactosaminyltransferase 1 (B4GALNT1) encodes the key enzyme B4GALNT1 to generate gangliosides GM2/GD2. GM2/GD2 gangliosides are surface glycolipids mainly found on brain neurons as well as peripheral nerves and skin melanocytes and are reported to exacerbate the malignant potential of melanomas.
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