MAB2241
ANTI-TAU (MAPT) Antibody
mouse monoclonal, Tau 12
别名:
G protein beta1/gamma2 subunit-interacting factor 1, Neurofibrillary tangle protein, Paired helical filament-tau, microtubule-associated protein tau, microtubule-associated protein tau, isoform 4
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关于此项目
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Clone:
Tau 12, monoclonal
Species reactivity:
human
Application:
WB
Citations:
19
产品名称
抗Tau抗体，克隆Tau 12, clone Tau 12, from mouse
biological source
mouse
antibody form
purified antibody
clone
Tau 12, monoclonal
species reactivity
human
technique(s)
western blot: suitable
isotype
IgG1κ
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
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相关类别
General description
50-68kda
微管相关蛋白或MAP与微管结构的微管蛋白亚基结合并调节其功能稳定性。在细胞中，MAP与单体和多聚微管蛋白结合。MAP与多聚微管蛋白的结合进一步稳定了更高阶微管蛋白结构的形成。MAP与微管结构的结合是通过微管亲和力调节激酶（MARK）的磷酸化介导的。磷酸化释放与微管结合的MAP，使结构不稳定，促使其分解。主要有两种 MAP类型，I，II。II型MAP包括MAP2，MAP4和tau，存在于神经组织中。脑组织中存在六种tau亚型，它们的结合结构域数量不同。三个亚型具有三个结合结构域，其他三个亚型具有四个结合结构域。结合结构域位于蛋白的羧基末端，并带正电（使其与带负电的微管结合）。具有四个结合结构域的亚型比具有三个结合结构域的亚型在稳定微管方面更好。
Immunogen
KLH偶联合成线性肽。
表位：N末端
Application
抗Tau抗体，克隆Tau 12是针对 Tau的抗体，用于 WB。
研究子类别
神经退行性疾病
神经退行性疾病
研究类别
神经科学
神经科学
Biochem/physiol Actions
与其他物种的反应性尚未确定。
目录号MAB2241识别Tau的N端区域。
Physical form
在含 0.05％NaN3 的 0.1M Tris-甘氨酸（pH7.4）150mM NaCl 中纯化。
形式：纯化
纯化的蛋白G
Preparation Note
自收到之日起，在 2-8ºC 条件下可稳定保存1年
Analysis Note
对照
人脑组织裂解物。
人脑组织裂解物。
蛋白质印迹:
Other Notes
替代品：MAB10417
浓度：请参考批次特异性浓缩物的分析证书。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Hiroki Takeuchi et al.
NPJ vaccines, 5, 28-28 (2020-03-29)
Pathological aggregates of tau proteins accumulate in the brains of neurodegenerative tauopathies including Alzheimer's disease and frontotemporal lobar degeneration (FTLD-tau). Although immunotherapies of these disorders against tau are emerging, it is unknown whether nasal delivery, which offers many benefits over
Michael J Ellis et al.
Acta neuropathologica, 147(1), 87-87 (2024-05-18)
Antibodies are essential research tools whose performance directly impacts research conclusions and reproducibility. Owing to its central role in Alzheimer's disease and other dementias, hundreds of distinct antibody clones have been developed against the microtubule-associated protein Tau and its multiple
April L Darling et al.
Protein science : a publication of the Protein Society, 30(7), 1350-1359 (2021-03-10)
Alzheimer's disease is a progressive fatal neurodegenerative disease with no cure or effective treatments. The hallmarks of disease include extracellular plaques and intracellular tangles of aggregated protein. The intracellular tangles consist of the microtubule associated protein tau. Preventing the pathological
Francesc X Guix et al.
International journal of molecular sciences, 19(3) (2018-03-03)
Progressive cerebral accumulation of tau aggregates is a defining feature of Alzheimer's disease (AD). A popular theory that seeks to explain the apparent spread of neurofibrillary tangle pathology proposes that aggregated tau is passed from neuron to neuron. Such a
Juan Ramón Perea et al.
Experimental neurology, 310, 14-21 (2018-08-24)
Tauopathies are a broad set of neurodegenerative dementias characterized by the aggregation of Tau protein. Activated microglia and elevated levels of pro-inflammatory molecules are also pathological hallmarks of tauopathies. In these diseases, intracellular Tau is secreted to the extracellular space
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