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MAB2502

抗原纤维蛋白1抗体，NT，克隆26

clone 26, Chemicon®, from mouse

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关于此项目

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
26, monoclonal
Application:
ELISA
immunocytochemistry
immunoprecipitation (IP)
western blot
Species reactivity:
human
Citations:
11
Technique(s):
ELISA: suitable
immunocytochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
Uniprot accession no.:
P35555

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产品名称

抗原纤维蛋白1抗体，NT，克隆26, clone 26, Chemicon®, from mouse

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

26, monoclonal

species reactivity

human

manufacturer/tradename

Chemicon®

technique(s)

ELISA: suitable
immunocytochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

isotype

IgG1

NCBI accession no.

NM_000138.3

UniProt accession no.

P35555

shipped in

wet ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... FBN1(2200)

相关类别

Application

免疫印迹

免疫荧光

免疫沉淀

ELISA

最佳工作稀释度必须由最终用户确定。
抗原纤维蛋白-1抗体，N末端（克隆26），可检测原纤维蛋白-1水平，&已有相关文献发表&通过ELISA、WB&IC应用验证。
研究子类别
ECM 蛋白
研究类别
细胞结构

Biochem/physiol Actions

单克隆抗体MAB2502可识别人原纤维蛋白-1。 表位图谱研究确定了该抗体与分子氨基末端的结合位点位于氨基酸残基 45 和 450 之间。 该抗体可与人、鸡和牛原纤维蛋白-1发生反应。

Disclaimer

除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

Immunogen

人原纤维蛋白-1
表位：N端

Physical form

1 mg/mL液体，溶于含0.1%叠氮化钠的20 mM磷酸盐缓冲液，250 mM NaCl，pH 7.6。注： 叠氮化钠有毒。 可根据要求提供MSDS。
形式：纯化

Preparation Note

以未稀释的等分形式可在2-8°C冷藏保存长达12个月。

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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存储类别

10 - Combustible liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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James C Tan et al.
Scientific reports, 14(1), 3517-3517 (2024-02-13)
Aqueous humor (AH) and blood levels of transforming growth factor β (TGFβ) are elevated in idiopathic primary open angle glaucoma (POAG) representing a disease biomarker of unclear status and function. Tsk mice display a POAG phenotype and harbor a mutation
Natalija Bogunovic et al.
Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists, 28(4), 604-613 (2021-04-28)
Abdominal aortic aneurysms (AAAs) are associated with overall high mortality in case of rupture. Since the pathophysiology is unclear, no adequate pharmacological therapy exists. Smooth muscle cells (SMCs) dysfunction and extracellular matrix (ECM) degradation have been proposed as underlying causes.
Nagako Yoshiba et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 63(6), 438-448 (2015-03-26)
Myofibroblasts and extracellular matrix are important components in wound healing. Alpha-smooth muscle actin (α-SMA) is a marker of myofibroblasts. Fibrillin-1 is a major constituent of microfibrils and an extracellular-regulator of TGF-β1, an important cytokine in the transdifferentiation of resident fibroblasts
Fibrillin microfibril structure identifies long-range effects of inherited pathogenic mutations affecting a key regulatory latent TGFI?-binding site.
Godwin, et al.
Nature Structural and Molecular Biology, 30, 608-618 (2023)
Rachel Morissette et al.
The Journal of clinical endocrinology and metabolism, 100(8), E1143-E1152 (2015-06-16)
The contiguous gene deletion syndrome (CAH-X) was described in a subset (7%) of congenital adrenal hyperplasia (CAH) patients with a TNXA/TNXB chimera, resulting in deletions of CYP21A2, encoding 21-hydroxylase necessary for cortisol biosynthesis, and TNXB, encoding the extracellular matrix glycoprotein

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