MAB2617
抗Kindlin-2抗体，克隆3A3
clone 3A3, from mouse
别名:
Mitogen-inducible gene 2 protein, Pleckstrin homology domain-containing family C member 1, fermitin family homolog 2, kindlin 2, mitogen inducible gene 2 protein
产品名称
抗Kindlin-2抗体，克隆3A3, clone 3A3, from mouse
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
3A3, monoclonal
species reactivity
human
species reactivity (predicted by homology)
bovine (based on 100% sequence homology), rat (98% sequence homology), mouse (98% sequence homology)
technique(s)
immunocytochemistry: suitable
western blot: suitable
isotype
IgG1κ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... FERMT2(10979)
Analysis Note
对照
HeLa细胞裂解物
HeLa细胞裂解物
通过蛋白质印迹在HeLa 细胞裂解物中进行了评估。
蛋白质印迹分析：0.5 µg/ml该抗体可在10 µg HeLa细胞裂解物中检测到Kindlin-2。
蛋白质印迹分析：0.5 µg/ml该抗体可在10 µg HeLa细胞裂解物中检测到Kindlin-2。
Application
研究子类别
细胞骨架
细胞骨架
研究类别
细胞结构
细胞结构
该抗Kindlin-2抗体克隆3A3经过验证可用在 WB，IC 中检测Kindlin-2。
Biochem/physiol Actions
该抗体识别Kindlin-2。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
Kindlin家族是一组黏着斑蛋白，由于它们具有结合和激活整联蛋白的能力而成为人们关注的焦点。这种能力的异常已将Kindlin与几种遗传和获得性疾病联系起来，例如Kindler综合征，癌症和白细胞粘附缺乏症。亚型Kindlin-2专门参与将migfilin蛋白募集到局部粘连位点以进行细胞ECM各种相互作用，协调肌动蛋白的生产和细胞形状的修饰。它还积极参与连接ECM粘连位点和肌动蛋白细胞骨架（Shi，2007）。Kindlin-2在整个组织中普遍表达。
~70 kDa
Immunogen
GST 标记的重组蛋白对应于人Kindlin-2。
表位：未知
Other Notes
浓度：请参考批次特异性浓缩物的分析证书。
Physical form
在含0.1 M Tris-甘氨酸（pH 7.4，150 mM NaCl）和0.05％叠氮化钠的缓冲液中的纯化的小鼠单克隆IgG1κ。
形式：纯化
纯化的蛋白G
Preparation Note
自收到之日起，在 2-8°C 条件下可稳定保存1年
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Lihua Qi et al.
FEBS letters, 589(16), 2155-2162 (2015-07-06)
Kindlin-2, as an integrin-interacting protein, was known to be required for the maintenance of cardiac structure and function in zebrafish. However, the mechanism remains unclear. We found that Kindlin-2 interacts and colocalizes with α-actinin-2 at the Z-disc of mouse cardiac
Lihua Qi et al.
Cell death & disease, 10(12), 890-890 (2019-11-27)
Kindlin-2 plays an important role in the regulation of cardiac structure and function. Depletion of Kindlin-2 contributes to cardiac hypertrophy and progressive heart failure, however, the precise mechanisms involved in this process remain unclear. GATA4 is a critical transcription factor
Jie Lin et al.
Journal of experimental & clinical cancer research : CR, 36(1), 134-134 (2017-10-04)
Kindlin-2 is a member of the focal adhesion protein family that regulates invasion and metastasis in multiple malignancies; however, little is known about the role of Kindlin-2 in hepatocellular carcinoma (HCC) progression. Immunohistochemistry was used to investigate Kindlin-2 expression in
Huanqing Gao et al.
JCI insight, 4(13) (2019-07-12)
Kindlin-2 regulates integrin-mediated cell adhesion to and migration on the extracellular matrix. Our recent studies demonstrate important roles of kindlin-2 in regulation of mesenchymal stem cell differentiation and skeletal development. In this study, we generated adipose tissue-specific conditional knockout of
Khalid Sossey-Alaoui et al.
Cancer research, 77(18), 5129-5141 (2017-07-09)
Interplay between tumor cells and host cells in the tumor microenvironment dictates the development of all cancers. In breast cancer, malignant cells educate host macrophages to adopt a protumorigenic phenotype. In this study, we show how the integrin-regulatory protein kindlin-2
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