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MAB2641

Anti-Fibrillin (Pan) Antibody, clone 689

Name: Anti-Fibrillin (Pan) Antibody, clone 689
Brand: MM

clone 689, from mouse

别名:

EGF-containing fibulin-like extracellular matrix protein 1, Fibrillin-like protein, Extracellular protein S1-5

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关于此项目

UNSPSC Code:

12352203

NACRES:

NA.41

eCl@ss:

32160702

Conjugate:

unconjugated

Clone:

689, monoclonal

Application:

ELISA, IHC

Citations:

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属性

biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

689, monoclonal

species reactivity

mouse

species reactivity (predicted by homology)

chicken (based on 100% sequence homology), human (based on 100% sequence homology)

technique(s)

ELISA: suitable, immunohistochemistry: suitable

isotype

IgG1κ

NCBI accession no.

NP_115823

UniProt accession no.

Q75N90

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... EFEMP1(2202)

说明

General description

~ 350 kDa calculated

Fibrillins are glycosolated and disulfide-rich components of the extracellular matrix belonging to the Fibrillin-LTBP protein family. They serve an important function in both nonelastic and elastic tissues such as eye, bone and blood vessels. The functional units of Fibrillin are known as microfibrils, multiprotein assemblies, which act as structural scaffolding for the limiting of the tissue elasticity, structural integrity of different organ systems, the assembly of elastic fibers, and regulation of BMP growth factor signaling. There are three known isoforms; Fibrillin 1, Fibrillin 2, and Fibrillin 3. Fibrillin 3 is the most recently described member of the Fibrillin family, with highest expression in the brain. Alterations in the microfibril assembly often occur in patients with fibrillinopathies such as; Congenital Contractual Arachnodactyly (CCA) which results in disruption of Fibrillin 2, and Marfan’s syndrome resulting from Fibrillin 1 mutation.

Immunogen

Recombinant protein corresponding to human Fibrillin 3.

Application

Anti-Fibrillin (Pan) Antibody, clone 689 detects level of Fibrillin (Pan) & has been published & validated for use in IH, ELISA.

ELISA Analysis: This antibody has been used by an independent laboratory in ELISA (Corson, 2003).

Biochem/physiol Actions

The antibody recognizes isoforms 1, 2, and 3 of fibrillin.

Physical form

Format: Purified

Analysis Note

Control
Mouse skin tissue

Evaluated by Immunohistochemistry in fresh frozen mouse skin tissue.

Immunohistochemistry Analysis: 1:200 dilution of the antibody detected Fibrillin (Pan) in fresh frozen mouse skin tissue.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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存储类别

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c