biological source
mouse
conjugate
unconjugated
antibody form
purified antibody
clone
8E10, monoclonal
species reactivity
canine, rabbit, feline, human, bovine, pig, goat
should not react with
rat, mouse, fish
manufacturer/tradename
Chemicon®
technique(s)
ELISA: suitable, western blot: suitable
isotype
IgG1
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
相关类别
Immunogen
游离人心肌肌钙蛋白1
表位:a.a.87-91
Application
使用经验证可用于ELISA & WB的该抗心肌肌钙蛋白I抗体检测心肌肌钙蛋白I。
研究子类别
肌肉生理学
肌肉生理学
研究类别
代谢
代谢
蛋白质印迹:识别14kDa和18kDa 两条条带,它们似乎是全长cTn1的分解产物(Morjana N, 1998,心肌梗死后人心肌肌钙蛋白I的降解,Biotechnol Appl. Biochem. 28:105-11)。
EIA:MAB3152已成功用于ELISA和免疫亲和纯化。 其亲和常数为8x10(10)。它可以和MAB3150一起用作夹心 ELISA的包被抗体。
最佳工作稀释度必须由最终用户进行确定。
EIA:MAB3152已成功用于ELISA和免疫亲和纯化。 其亲和常数为8x10(10)。它可以和MAB3150一起用作夹心 ELISA的包被抗体。
最佳工作稀释度必须由最终用户进行确定。
Biochem/physiol Actions
MAB3152与游离心肌肌钙蛋白1(cTn1)和cTn1 均等地反应,与其它肌钙蛋白形成复合物。 它可以识别没有受到其它肌钙蛋白成分扰动或空间屏蔽的其它表位。 不受肝素、磷酸化、氧化和复合物形成的影响。 可识别位于cTnI氨基酸残基87和91之间的表位。它与骨骼肌肌钙蛋白1没有交叉反应。
Physical form
含有0.1%叠氮化钠的PBS (pH 7.4)中的液体。
形式:纯化
Preparation Note
以未稀释的等分形式可在2-8°C冷藏保存长达6个月。
Other Notes
浓度:请参考批次特异性浓缩物的检验报告。
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
J Scott Pattison et al.
Circulation research, 109(2), 151-160 (2011-05-28)
Increasing evidence suggests that misfolded proteins and intracellular aggregates contribute to cardiac disease and heart failure. Several cardiomyopathies, including the αB-crystallin R120G mutation (CryAB(R120G)) model of desmin-related cardiomyopathy, accumulate cytotoxic misfolded proteins in the form of preamyloid oligomers and aggresomes.
Xian Long et al.
Molecular medicine reports, 24(5) (2021-09-21)
Septicemia is associated with excessive inflammation, oxidative stress and apoptosis, causing myocardial injury that results in high mortality and disability rates worldwide. The abnormal expression of multiple microRNAs (miRNAs/miRs) is associated with more severe sepsis‑induced myocardial injury (SIMI) and miR‑335
Yanni Ma et al.
The EMBO journal, 34(3), 361-378 (2014-12-19)
MicroRNAs play important roles in controlling the embryonic stem cell (ESC) state. Although much is known about microRNAs maintaining ESC state, microRNAs that are responsible for promoting ESC differentiation are less reported. Here, by screening 40 microRNAs pre-selected by their
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MOUSE ANTI-HUMAN CARDIAC TROPONIN 1
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