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Merck
CN

MAB348B

Sigma-Aldrich

Anti-Alzheimer Precursor Protein A4 Antibody, clone 22C11, Biotin Conj. | MAB348B

clone 22C11, from mouse, biotin conjugate

别名:

Amyloid beta A4 protein, ABPP, APPI, APP, Alzheimer disease amyloid protein, Cerebral vascular amyloid peptide, CVAP, PreA4, Protease nexin-II, PN-II, N-APP, Soluble APP-alpha, S-APP-alpha, Soluble APP-beta, S-APP-beta, C99, Beta-amyloid protein 42, Beta

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关于此项目

UNSPSC代码:
12352203
eCl@ss:
32160702
NACRES:
NA.41

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生物来源

mouse

偶联物

biotin conjugate

抗体形式

purified immunoglobulin

抗体产品类型

primary antibodies

克隆

22C11, monoclonal

种属反应性

rat, pig

种属反应性（根据同源性预测）

porcine (based on 100% sequence homology), mouse (based on 100% sequence homology), monkey (based on 100% sequence homology), human (based on 100% sequence homology), canine (based on 100% sequence homology)

技术

immunocytochemistry: suitable
immunohistochemistry: suitable

同位素/亚型

IgG1

NCBI登记号

NP_000475

UniProt登记号

P05067

运输

wet ice

靶向翻译后修饰

unmodified

基因信息

human ... APP(351)

一般描述

Deposits of amyloid protein in senile plaques near nerve processes are found in the brains of aged humand and cases of Alzheimer′s Disease. The principle component of this extracellular amyloid is beta A4, a 4 kDa peptide derived from a larger amyloid precursor protein (APP), which is widely expressed in the brain and body. The creation, transport and function of these proteins is currently an active area of research.
Varies

免疫原

Epitope: N-terminus
Purified recombinant Alzheimer precursor A4 (pre A4695) fusion protein

应用

Evaluated by Immunohistochemistry in adult rat brain tissue.

Immunohistochemistry Analysis: A 1:100 dilution of this antibody detected Alzheimer Precursor Protein A4 in adult rat brain tissue.
Research Category
Neuroscience
Research Sub Category
Neurodegenerative Diseases

生化/生理作用

This antibody recognizes Alzheimer Precursor Protein A4 at the N-temrinus.

外形

Protein A purified
Purified mouse monoclonal IgG1 conjugated to Biotin in PBS with 0.1% sodium azide and 15 mg/mL BSA.

制备说明

Stable for 1 year at 2-8°C from date of receipt.

分析说明

Control
Rat E18 primary cortex cells
Evaluated by Immunocytochemistry in rat E18 primary cortex cells.

Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected Alzheimer Precursor Protein A4 in rat E18 primary cortex cells.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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储存分类代码

12 - Non Combustible Liquids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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Frances K Wiseman et al.
Brain : a journal of neurology, 141(8), 2457-2474 (2018-06-27)
Down syndrome, caused by trisomy of chromosome 21, is the single most common risk factor for early-onset Alzheimer's disease. Worldwide approximately 6 million people have Down syndrome, and all these individuals will develop the hallmark amyloid plaques and neurofibrillary tangles
Ahsan Habib et al.
Cell transplantation, 27(3), 438-455 (2018-03-22)
Alzheimer's disease (AD) is an age-related disorder that affects cognition. Our previous studies showed that the neuroprotective fragment of amyloid procurer protein (APP) metabolite, soluble APPα (sAPPα), interferes with β-site APP-cleaving enzyme 1 (BACE1, β-secretase) cleavage and reduces amyloid-β (Aβ)

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