产品名称
抗胱天冬酶 2抗体，克隆11B4, clone 11B4, Chemicon®, from rat
biological source
rat
conjugate
unconjugated
antibody form
purified antibody
antibody product type
primary antibodies
clone
11B4, monoclonal
species reactivity
mouse, monkey, human, canine
manufacturer/tradename
Chemicon®
technique(s)
ELISA: suitable
flow cytometry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
isotype
IgG2a
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... CASP2(835)
Application
抗半胱天冬酶 2 抗体（克隆11B4）是一种针对半胱天冬酶 2的抗体，可用于ELISA、FC、IP & WB。
研究子类别
胱天蛋白酶
酶&生物化学
胱天蛋白酶
酶&生物化学
研究类别
细胞凋亡 & 癌症
代谢
细胞凋亡 & 癌症
代谢
蛋白质印迹：推荐在 5 μg/ml下使用，该浓度可以在5 x 10E5 HeLa 和MCF-7 细胞中检测到内源性半胱天冬酶2。
免疫沉淀：建议浓度1-5 μg/ml FACS：建议浓度1μ g/mL。 分析以前需要透化细胞膜。
EIA：建议浓度0.5-1 μg/mL。
免疫组化：在10-20 μg/mL下使用 在染色前需要在4%多聚甲醛/0.18% Triton-X100中固定细胞10分钟。
最佳工作稀释度必须由最终用户进行确定。
免疫沉淀：建议浓度1-5 μg/ml FACS：建议浓度1μ g/mL。 分析以前需要透化细胞膜。
EIA：建议浓度0.5-1 μg/mL。
免疫组化：在10-20 μg/mL下使用 在染色前需要在4%多聚甲醛/0.18% Triton-X100中固定细胞10分钟。
最佳工作稀释度必须由最终用户进行确定。
Biochem/physiol Actions
MAB3507抗体可识别位于人半胱天冬酶2（ICH-1，Nedd-2）P19亚基的反应性表位。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
Immunogen
针对人半胱天冬酶2肽的P19亚基而产生。
Other Notes
替代：04-571
浓度：请参考批次特异性浓缩物的检验报告。
Physical form
含0.05%Bronidox 防腐剂的液体。
形式：纯化
Preparation Note
以未稀释的等分形式可在2-8°C冷藏保存长达12个月。
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
M J Parsons et al.
Cell death and differentiation, 20(9), 1174-1182 (2013-05-07)
Despite being the most evolutionarily conserved of the mammalian caspases, little is understood about the cellular function of caspase-2 in normal tissues or what role caspase-2 may have in the progression of human disease. It has been reported that deletion
Brittany L Carroll et al.
FEBS open bio, 8(1), 27-40 (2018-01-13)
Sphingosine kinase 1 (SK1) is a lipid kinase whose activity produces sphingosine 1-phosphate, a prosurvival lipid associated with proliferation, angiogenesis, and invasion. SK1 overexpression has been observed in numerous cancers. Recent studies have demonstrated that SK1 proteolysis occurs downstream of
Christopher J Del Nagro et al.
Cell cycle (Georgetown, Tex.), 13(2), 303-314 (2013-11-20)
Activation of Checkpoint kinase 1 (Chk1) following DNA damage mediates cell cycle arrest to prevent cells with damaged DNA from entering mitosis. Here we provide a high-resolution analysis of cells as they undergo S- and G₂-checkpoint bypass in response to
L Dorstyn et al.
Cell death and differentiation, 19(8), 1288-1298 (2012-04-14)
Caspase-2 is an initiator caspase, which has been implicated to function in apoptotic and non-apoptotic signalling pathways, including cell-cycle regulation, DNA-damage signalling and tumour suppression. We previously demonstrated that caspase-2 deficiency enhances E1A/Ras oncogene-induced cell transformation and augments lymphomagenesis in
Ramaswamy Sharma et al.
PloS one, 9(4), e93696-e93696 (2014-04-03)
Osteoporosis is a silent disease, characterized by a porous bone micro-structure that enhances risk for fractures and associated disabilities. Senile, or age-related osteoporosis (SO), affects both men and women, resulting in increased morbidity and mortality. However, cellular and molecular mechanisms
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