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Merck
CN

MAB4122

Anti-Multi-Drug Resistance Related Protein Antibody, clone MRPm6

culture supernatant, clone MRPm6, Chemicon®

别名:

MRP

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关于此项目

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Clone:
MRPm6, monoclonal
Species reactivity:
human
Application:
flow cytometry
immunohistochemistry
western blot
Technique(s):
flow cytometry: suitable
immunohistochemistry: suitable (paraffin)
western blot: suitable
Citations:
6
Uniprot accession no.:
P33527

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产品名称

Anti-Multi-Drug Resistance Related Protein Antibody, clone MRPm6, culture supernatant, clone MRPm6, Chemicon®

biological source

mouse

antibody form

culture supernatant

antibody product type

primary antibodies

clone

MRPm6, monoclonal

species reactivity

human

manufacturer/tradename

Chemicon®

technique(s)

flow cytometry: suitable
immunohistochemistry: suitable (paraffin)
western blot: suitable

isotype

IgG1

NCBI accession no.

NM_004996.3
NM_019862.2
NM_019898.2
NM_019899.2
NM_019900.2
NM_019901.1
NM_019902.1

UniProt accession no.

P33527

shipped in

wet ice

Quality Level

300

Gene Information

human ... ABCC1(4363)

相关类别

Application

Anti-Multi-Drug Resistance Related Protein Antibody, clone MRPm6 is an antibody against Multi-Drug Resistance Related Protein for use in FC, WB, IH(P).
Western blot

Flow Cytometry

Immunohistochemistry on frozen and paraffin embedded tissue

sections: 1:20.

Note: For cellular detection permeabilization is required.

Optimal working dilutions must be determined by end user.

Biochem/physiol Actions

MRPm6 reacts with an internal epitope of MRP, a 180-195 kDa transmembrane transporter protein overexpressed in various human non-P-glycoprotein MDR tumor cell lines. MRPm6 was raised against a bacterial fusion protein of MRP, containing a segment of 170 amino acids in the carboxy terminal end and part of the carboxy proximal nucleotide binding domain of the protein. MRPm6 does not cross-react with the human MDR1 and MDR3 gene products (Flens et al., 1994).

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Physical form

Tissue Culture Supernatant. Liquid containing 0.1% sodium azide and 0.7% BSA.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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存储类别

10 - Combustible liquids

wgk

WGK 2

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M L Den Boer et al.
Leukemia, 11(7), 1078-1085 (1997-07-01)
The clinical relevance of multidrug resistance (MDR)-related proteins in childhood acute lymphoblastic leukemia (ALL) is largely unknown. The diversity of techniques, fixation methods, storage of cells (fresh or cryopreserved) etc, may contribute to discrepancies observed between several studies. We therefore
D Schadendorf et al.
The American journal of pathology, 147(6), 1545-1552 (1995-12-01)
Melanoma cells often display a multidrug-resistant phenotype, but the mechanisms involved are largely unknown. We have studied here the recently identified transport-associated proteins, MRP and LRP, and the well-known drug resistance marker P-glycoprotein using a panel of 16 human melanoma
Tissue distribution of the multidrug resistance protein.
Flens, M J, et al.
The American Journal of Pathology, 148, 1237-1247 (1996)

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