产品名称
Anti-MDR3 Antibody, clone P3 II-26, culture supernatant, clone P3 II-26, Chemicon®
biological source
mouse
antibody form
culture supernatant
antibody product type
primary antibodies
clone
P3 II-26, monoclonal
species reactivity
human
manufacturer/tradename
Chemicon®
technique(s)
immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable
isotype
IgG2b
suitability
not suitable for immunohistochemistry (Paraffin)
NCBI accession no.
UniProt accession no.
shipped in
wet ice
Quality Level
Gene Information
human ... ABCB4(5244)
Application
Anti-MDR3 Antibody, clone P3 II-26 is an antibody against MDR3 for use in WB, IC, IH.
Western Blotting: MDR3 is a 140 kDa protein.
Immunocytochemistry: 1:20 - 1:50 on acetone-fixed cytospin preparations
Immunohistochemistry: 1:20 on acetone-fixed frozen sections
Not suitable for paraffin-embedded tissues
Optimal working dilutions must be determined by end user.
Immunocytochemistry: 1:20 - 1:50 on acetone-fixed cytospin preparations
Immunohistochemistry: 1:20 on acetone-fixed frozen sections
Not suitable for paraffin-embedded tissues
Optimal working dilutions must be determined by end user.
Biochem/physiol Actions
This antibody reacts with an internal epitope of MDR3 P-gp. It does not cross-react with the human MDR1 P-gp. It has been reported that this clone also cross reacts with mouse MDR2 Pgp {Kok et al 2003 {http://www.biochemj.org/bj/369/0539/3690539.pdf}.
Immunogen
Mab was selected after immunization with a fusion protein consisting of Gluthatione-S-Transferase and a fragment of MDR3 P-gp comprising aa 629-692.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Preparation Note
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
10 - Combustible liquids
wgk
WGK 2
Tineke Kok et al.
The Biochemical journal, 369(Pt 3), 539-547 (2002-10-17)
Peroxisome proliferator-activated receptor alpha (PPARalpha) is a nuclear receptor that controls expression of genes involved in lipid metabolism and is activated by fatty acids and hypolipidaemic fibrates. Fibrates induce the hepatic expression of murine multidrug resistance 2 ( Mdr2 )
G J Hooiveld et al.
Gastroenterology, 117(3), 678-687 (1999-08-28)
Biliary cholesterol secretion is coupled to that of phospholipids in a process controlled by mdr2 P-glycoprotein activity and bile salt secretion. Statins, the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors, have been shown to affect hepatobiliary lipid secretion in rats. The aim
G L Scheffer et al.
Cancer research, 60(18), 5269-5277 (2000-10-04)
Tumor cells may display a multidrug resistance phenotype by overexpression of ATP binding cassette transporter genes such as multidrug resistance (MDR) 1 P-glycoprotein (P-gp) or the multidrug resistance protein 1 (MRP1). MDR3 P-gp is a close homologue of MDR1 P-gp
Denis A Evseenko et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 290(5), R1357-R1365 (2005-12-03)
ATP-binding cassette (ABC) efflux transporters are expressed in the human placenta where they are thought to help protect the fetus from xenobiotics. To evaluate models for analysis of ABC transporter function and regulation in the placenta, we have characterized the
Cifford W Mason et al.
Drug metabolism and disposition: the biological fate of chemicals, 39(6), 1000-1007 (2011-03-25)
Fetal drug exposure is determined by the type and concentration of placental transporters, and their regulation is central to the development of new treatments and delivery strategies for pregnant women and their fetuses. We tested the expression of several clinically
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