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MAB4162

抗-MDR1抗体，细胞外人类特异性Pgp，克隆号MM4.17

clone MM4.17, Chemicon®, from mouse

别名:

P-glycoprotein, CD243, p170, Pgp

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关于此项目

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Clone:
MM4.17, monoclonal
Species reactivity:
human
Application:
FACS, IHC
Citations:
5
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biological source

mouse

Quality Level

300

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

MM4.17, monoclonal

species reactivity

human

manufacturer/tradename

Chemicon®

technique(s)

flow cytometry: suitable, immunohistochemistry: suitable

isotype

IgG2aκ

NCBI accession no.

NM_000927.3

UniProt accession no.

P08183

shipped in

wet ice

Application

抗-MDR1抗体，细胞外人类特异性Pgp，克隆号MM4.17是一种抗MDR1抗体，用于FC、IH。
流式细胞术

丙酮固定石蜡包埋切片的免疫组化

共聚焦和电子显微镜

ELISA

最佳工作稀释度必须由最终用户进行确定。

Biochem/physiol Actions

识别细胞外Pgp结构域的一个表位，并在活（完整）人类MDR细胞中检测低水平的Pgp表达（Cianfriglia，2002）。 使用不同的技术将表位定位到单氨基酸水平（Cianfriglia，1994和Poloni，1995）。

Physical form

形式：纯化

Other Notes

浓度：请参考批次特异性浓缩物的检验报告。

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

存储类别

12 - Non Combustible Liquids

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Paola Turella et al.
The Journal of biological chemistry, 281(33), 23725-23732 (2006-06-14)
The new glutathione S-transferase inhibitor 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) is cytotoxic toward P-glycoprotein-overexpressing tumor cell lines, i.e. CEM-VBL10, CEM-VBL100, and U-2 OS/DX580. The mechanism of cell death triggered by NBDHEX has been deeply investigated in leukemia cell lines. Kinetic data indicate a
Jingwei Zhang et al.
British journal of pharmacology, 165(1), 120-134 (2011-05-28)
Intracellular pharmacokinetics of anticancer drugs in multi-drug resistance (MDR) cancer cells is hugely important in the evaluation and improvement of drug efficacy. By using adriamycin as a probe drug in MDR cancer cells, we developed a cellular pharmacokinetic-pharmacodynamic (PK-PD) model
Masahiro Yasunaga et al.
Scientific reports, 4, 4852-4852 (2014-05-02)
The treatment of colorectal cancer (CRC) might be improved by the identification of a signalling pathway that could be targeted with novel therapeutics. The results of this study indicate that the taurine transporter SLC6A6 is highly expressed in CRC cells
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货号GTIN
MAB416204053252660290