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Merck
CN

MAB4418

抗-无刚毛鳞甲同系物2抗体,克隆7E2

clone 7E2, from mouse

别名:

achaete-scute complex (Drosophila) homolog-like 2, achaete-scute complex homolog 2 (Drosophila), achaete-scute complex homolog-like 2, achaete-scute complex-like 2, achaete-scute complex-like 2 (Drosophila), mammalian achaete/scute homologue 2

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关于此项目

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
7E2, monoclonal
Application:
ChIP, ICC, WB
Citations:
11
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biological source

mouse

Quality Level

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

7E2, monoclonal

species reactivity

human

technique(s)

ChIP: suitable, immunocytochemistry: suitable, western blot: suitable

isotype

IgG2bκ

NCBI accession no.

UniProt accession no.

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... ASCL2(430)

General description

Achaete Scute同系物2(也称为哺乳动物无刚毛鳞甲同系物2或Mash2)是在发育中的胎盘的绒毛外滋养细胞中特异性表达的核蛋白。胎盘发育涉及基本螺旋-环-螺旋转录因子Achaete Scute同系物2的控制,其可以调节海绵滋养细胞形成中的HIF(缺氧)。Achaete Scute同系物2的定向诱变产生功能丧失导致妊娠中期胚胎致死,这是由于胎盘衰竭与海绵滋养细胞缺乏和迷宫滋养细胞层减少有关。除了健康的胎盘发育外,Achaete Scute蛋白还可能参与中枢和周围神经系统神经元前体的测定。Achaete Scute同系物2也被认为是肠干细胞命运的控制者,并且是维持成人肠干细胞所必需的(Tanaka,M.,et al.,(1997)Dev Biol. 190(10):55-65)。
约20 kDa

Immunogen

His标记的重组蛋白,对应于C末端附近的人Achaete Scute同系物2。

Application

免疫细胞化学分析: 一个先前批次被独立实验室用于IC(Van de Flier,L.G.,et al.,2009)

染色质免疫沉淀分析: 一个先前批次被独立实验室用于ChIP(Hatzis,P.,et al.,2008)。
抗Achaete Scute同系物2抗体,克隆7E2检测Achaete Scute同系物2的水平,&已发布&验证可用于WB、IC、ChIP。

Biochem/physiol Actions

该抗体识别C末端附近的Achaete Scute同系物2。

Physical form

形式:纯化

Analysis Note

通过蛋白质印迹法在人胎盘组织裂解物中进行评价。

蛋白质印迹分析:1 µg/mL的该抗体在10 µg人胎盘组织裂解物上检测到Achaete Scute同系物2。

Other Notes

浓度:关于批次特定浓度请参见检验报告。


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存储类别

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable



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Jarom Heijmans et al.
Cell reports, 3(4), 1128-1139 (2013-04-03)
Stem cells generate rapidly dividing transit-amplifying cells that have lost the capacity for self-renewal but cycle for a number of times until they exit the cell cycle and undergo terminal differentiation. We know very little of the type of signals
Genta Nagae et al.
Nature communications, 12(1), 5423-5423 (2021-09-21)
Hepatoblastoma (HB) is the most common pediatric liver malignancy; however, hereditary predisposition and acquired molecular aberrations related to HB clinicopathological diversity are not well understood. Here, we perform an integrative genomic profiling of 163 pediatric liver tumors (154 HBs and
Jun Ye et al.
Cell cycle (Georgetown, Tex.), 17(8), 1014-1025 (2018-06-12)
The Wnt signaling pathway controls stem cell identity in the intestinal epithelium and cancer stem cells (CSCs). The transcription factor Ascl2 (Wnt target gene) is fate decider of intestinal cryptic stem cells and colon cancer stem cells. It is unclear



全球贸易项目编号

货号GTIN
MAB441804053252577031